| Description : |
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
59.75 kDa |
| AA Sequence : |
MGPSCPVFLSFTKLSLWWLLLIPAG GEEAKRPPPRAPGDPLSSPSPTALP QGGSHTETEDRLFKHLFRGYNRWAR PVPNTSDVVIVRFGLSIAQLIDVDE KNQMMTTNVWLKQEWSDYKLRWNPA DFGNITSLRVPSEMIWIPDIVLYNN ADGEFAVTHMTKAHLFSTGTVHWVP PAIYKSSCSIDVTFFPFDQQNCKMK FGSWTYDKAKIDLEQMEQTVDLKDY WESGEWAIVNATGTYNSKKYDCCAE IYPDVTYAFVIRRLPLFYTINLIIP CLLISCLTVLVFYLPSDCGEKITLC ISVLLSLTVFLLLITEIIPSTSLVI PLIGEYLLFTMIFVTLSIVITVFVL NVHHRSPSTHTMPHWVRGALLGCVP RWLLMNRPPPPVELCHPLRLKLSPS YHWLESNVDAEEREVVVEEEDRWAC AGHVAPSVGTLCSHGHLHSGASGPK AEALLQEGELLLSPHMQKALEGVHY IADHLRSEDADSSVKEDWKYVAMVI DRIFLWLFIIVCFLGTIGLFLPPFL AGMITRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
