Recombinant Human CNOT7 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CNOT7-4189H
• Product Overview: CNOT7 MS Standard C13 and N15-labeled recombinant protein (NP_037486) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 32.7 kDa
• AA Sequence: MPAATVDHSQRICEVWACNLDEEMK KIRQVIRKYNYVAMDTEFPGVVARP IGEFRSNADYQYQLLRCNVDLLKII QLGLTFMNEQGEYPPGTSTWQFNFK FNLTEDMYAQDSIELLTTSGIQFKK HEEEGIETQYFAELLMTSGVVLCEG VKWLSFHSGYDFGYLIKILTNSNLP EEELDFFEILRLFFPVIYDVKYLMK SCKNLKGGLQEVAEQLELERIGPQH QAGSDSLLTGMAFFKMREMFFEDHI DDAKYCGHLYGLGSGSSYVQNGTGN AYEEEANKQSTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CNOT7 CCR4-NOT transcription complex subunit 7 [ Homo sapiens (human) ]
• Official Symbol: CNOT7
• Synonyms: CNOT7; CCR4-NOT transcription complex, subunit 7; CAF1; CCR4-NOT transcription complex subunit 7; BTG1 binding factor 1; CAF-1; BTG1-binding factor 1; CCR4-associated factor 1; carbon catabolite repressor protein (CCR4)-associative factor 1; hCAF-1
• Gene ID: 29883
• mRNA Refseq: NM_013354
• Protein Refseq: NP_037486
• MIM: 604913
• UniProt ID: Q9UIV1