Recombinant Human COMMD1, His-tagged

• Cat.No.: COMMD1-28014TH
• Product Overview: Recombinant full length Human COMMD1/MURR1 protein with an N terminal His tag; 210 amino acids ; predicted mwt: 23.3 kDa.

Specification

• Description: COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al.
• Protein length: 190 amino acids
• Conjugation: HIS
• Molecular Weight: 23.300kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMAAGE LEGGKPLSGLLNALAQDTFHGYPGI TEELLRSQLYPEVPPEEFRPFLAKM RGILKSIASADMDFNQLEAFLTAQT KKQGGITSDQAAVISKFWKSHKTKI RESLMNQSRWNSGLRGLSWRVDGKS QSRHSAQIHTPVAIIELELGKYGQE SEFLCLEFDEVKVNQILKTLSEVEE SISTLISQPN
• Sequence Similarities: Contains 1 COMM domain.

Gene Information

• Gene Name: COMMD1 copper metabolism (Murr1) domain containing 1 [ Homo sapiens ]
• Official Symbol: COMMD1
• Synonyms: COMMD1; copper metabolism (Murr1) domain containing 1; C2orf5, chromosome 2 open reading frame 5 (MURR1); COMM domain-containing protein 1; copper metabolism gene MURR1; MGC27155; MURR1
• Gene ID: 150684
• mRNA Refseq: NM_152516
• Protein Refseq: NP_689729
• MIM: 607238
• Uniprot ID: Q8N668
• Chromosome Location: 2p15
• Pathway: TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem
• Function: copper ion binding; identical protein binding; metal ion binding; protein binding; protein homodimerization activity