Recombinant Human COPS5 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: COPS5-4129H
• Product Overview: COPS5 MS Standard C13 and N15-labeled recombinant protein (NP_006828) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 37.6 kDa
• AA Sequence: MAASGSGMAQKTWELANNMQEAQSI DEIYKYDKKQQQEILAAKPWTKDHH YFKYCKISALALLKMVMHARSGGNL EVMGLMLGKVDGETMIIMDSFALPV EGTETRVNAQAAAYEYMAAYIENAK QVGRLENAIGWYHSHPGYGCWLSGI DVSTQMLNQQFQEPFVAVVIDPTRT ISAGKVNLGAFRTYPKGYKPPDEGP SEYQTIPLNKIEDFGVHCKQYYALE VSYFKSSLDRKLLELLWNKYWVNTL SSSSLLTNADYTTGQVFDLSEKLEQ SEAQLGRGSFMLGLETHDRKSEDKL AKATRDSCKTTIEAIHGLMSQVIKD KLFNQINISTRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: COPS5 COP9 signalosome subunit 5 [ Homo sapiens (human) ]
• Official Symbol: COPS5
• Synonyms: COPS5; COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5; COP9 signalosome complex subunit 5; CSN5; JAB1; MOV 34; SGN5; 38 kDa Mov34 homolog; signalosome subunit 5; jun activation domain-binding protein 1; MOV-34; MGC3149
• Gene ID: 10987
• mRNA Refseq: NM_006837
• Protein Refseq: NP_006828
• MIM: 604850
• UniProt ID: Q92905