Recombinant Human CRK, GST-tagged
Cat.No. : | CRK-11582H |
Product Overview : | Recombinant Human CRK protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | C-term-264a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | CRK v-crk sarcoma virus CT10 oncogene homolog (avian) [ Homo sapiens ] |
Official Symbol : | CRK |
Synonyms : | CRK; v-crk sarcoma virus CT10 oncogene homolog (avian); v crk avian sarcoma virus CT10 oncogene homolog; adapter molecule crk; proto-oncogene c-Crk; p38; CRKII; FLJ38130; |
Gene ID : | 1398 |
mRNA Refseq : | NM_005206 |
Protein Refseq : | NP_005197 |
MIM : | 164762 |
UniProt ID : | P46108 |
Chromosome Location : | 17p13 |
Pathway : | ARMS-mediated activation, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; |
Function : | SH2 domain binding; SH3/SH2 adaptor activity; ephrin receptor binding; protein binding; protein phosphorylated amino acid binding; |
Products Types
◆ Recombinant Protein | ||
CRK-1260R | Recombinant Rat CRK Protein, His (Fc)-Avi-tagged | +Inquiry |
CRK-1886H | Recombinant Human CRK Protein, GST-tagged | +Inquiry |
Crk-2313M | Recombinant Mouse Crk Protein, Myc/DDK-tagged | +Inquiry |
CRK-661H | Recombinant Human CRK Protein, His (Fc)-Avi-tagged | +Inquiry |
CRK-1771C | Recombinant Chicken CRK | +Inquiry |
◆ Lysates | ||
CRK-7277HCL | Recombinant Human CRK 293 Cell Lysate | +Inquiry |
CRK-7276HCL | Recombinant Human CRK 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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