Recombinant Human CTGF
Cat.No. : | CTGF-28023TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 253-350 of Human CTGF, a 11.2 kDa protein of 98 amino acid residues which exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. |
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Description : | The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. |
Source : | E. coli |
Tissue specificity : | Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. |
Biological activity : | Biological Activity : Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1.0-2.0 μg/ml. |
Form : | Lyophilised |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Spin down vial and reconstitute in distilled water for a concentration of 0.1 - 1.0 mg/ml. |
Storage : | The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. |
Sequences of amino acids : | MGKKCIRTPK ISKPIKFELS GCTSMKTYRA KFCGVCTDGR CCTPHRTTTL PVEFKCPDGE VMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA |
Sequence Similarities : | Belongs to the CCN family.Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 TSP type-1 domain.Contains 1 VWFC domain. |
Gene Name : | CTGF connective tissue growth factor [ Homo sapiens ] |
Official Symbol : | CTGF |
Synonyms : | CTGF; connective tissue growth factor; CCN2; IGFBP8; |
Gene ID : | 1490 |
mRNA Refseq : | NM_001901 |
Protein Refseq : | NP_001892 |
MIM : | 121009 |
Uniprot ID : | P29279 |
Chromosome Location : | 6q23.2 |
Pathway : | Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem; TGF-beta receptor signaling, organism-specific biosystem; amb2 Integrin signaling, organism-specific biosystem; |
Function : | fibronectin binding; growth factor activity; heparin binding; insulin-like growth factor binding; |
Products Types
◆ Recombinant Protein | ||
CTGF-1287H | Recombinant Human CTGF Protein, His&GST-tagged | +Inquiry |
CTGF-1313R | Recombinant Rat CTGF Protein, His (Fc)-Avi-tagged | +Inquiry |
CTGF-865R | Recombinant Rabbit CTGF Protein, His-tagged | +Inquiry |
CTGF-2795H | Recombinant Human CTGF Protein, His-tagged, OVA Conjugated | +Inquiry |
CTGF-2069H | Recombinant Human CTGF Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
CTGF-7205HCL | Recombinant Human CTGF 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCTGF levels can be measured using various techniques, including enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry.
CTGF levels can serve as diagnostic markers for fibrotic diseases, aiding in the early detection and monitoring of such conditions.
Yes, targeting CTGF is being explored as a potential therapeutic strategy to mitigate fibrosis in various organs and tissues.
CTGF protein research is particularly relevant in specialties such as rheumatology, pulmonology, and dermatology due to its implications in fibrotic diseases.
CTGF plays a crucial role in promoting the formation of fibrous tissue by stimulating the production of extracellular matrix proteins.
Customer Reviews (3)
Write a reviewIts purity, stability, and consistency ensure reliable and reproducible results, giving me confidence in the integrity of my research findings.
With their assistance, I can overcome obstacles and optimize my experimental setup.
With the CTGF protein and the manufacturer's support, I am confident in obtaining accurate and meaningful results for my scientific investigations.
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