Recombinant Human CXCR4 Full Length Transmembrane protein, His-SUMO-tagged

• Cat.No.: CXCR4-2365H
• Product Overview: Recombinant Human CXCR4 protein(P61073)(1-356aa), fused to N-terminal His-SUMO tag, was expressed in E. coli.

Specification

• Source: In vitro E. coli expression system
• Species: Human
• Tag: His-SUMO
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 55.7kDa
• Protein Length: 1-356aa
• AA Sequence: MSIPLPLLQIYTSDNYTEEMGSGDY DSMKEPCFREENANFNKIFLPTIYS IIFLTGIVGNGLVILVMGYQKKLRS MTDKYRLHLSVADLLFVITLPFWAV DAVANWYFGNFLCKAVHVIYTVNLY SSVLILAFISLDRYLAIVHATNSQR PRKLLAEKVVYVGVWIPALLLTIPD FIFANVSEADDRYICDRFYPNDLWV VVFQFQHIMVGLILPGIVILSCYCI IISKLSHSKGHQKRKALKTTVILIL AFFACWLPYYIGISIDSFILLEIIK QGCEFENTVHKWISITEALAFFHCC LNPILYAFLGAKFKTSAQHALTSVS RGSSLKILSKGKRGGHSSVSTESES SSFHSS
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: CXCR4 chemokine (C-X-C motif) receptor 4 [ Homo sapiens ]
• Official Symbol: CXCR4
• Synonyms: CXCR4; chemokine (C-X-C motif) receptor 4; chemokine (C X C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CD184; D2S201E; fusin; HM89; HSY3RR; LESTR; NPY3R; NPYR; NPYY3R; CXC-R4; CXCR-4; CD184 antigen; SDF-1 receptor; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; FB22; LAP3; LCR1; WHIM; NPYRL
• Gene ID: 7852
• mRNA Refseq: NM_001008540
• Protein Refseq: NP_001008540
• MIM: 162643
• UniProt ID: P61073

Reviews

04/07/2022

The responsive customer support team provided quick resolutions to any queries or issues we encountered.

10/28/2021

The product's cost-effectiveness and clear instructions were instrumental in our experimental design.

10/29/2018

We found the product's straightforward protocols highly conducive to seamless integration into our lab work.

Q&As

How does CXCR4 participate in chemotaxis and migration of immune cells, particularly in the context of the immune response?

CXCR4 participates in chemotaxis and migration of immune cells, facilitating their movement toward specific tissues during the immune response.

Are there specific chemokines or ligands that CXCR4 binds to, influencing its role in immune cell activation and recruitment?

Specific chemokines or ligands, such as CXCL12, bind to CXCR4, influencing its role in immune cell activation and recruitment.

In which cellular compartments is CXCR4 predominantly localized, especially within immune cells?

CXCR4 is predominantly localized on the cell surface of immune cells, particularly within the membrane of T cells and monocytes.

What diseases or conditions are associated with dysregulation or abnormal expression of CXCR4, especially in the immune system?

Dysregulation or abnormal expression of CXCR4 is associated with diseases such as cancer, HIV/AIDS, and autoimmune disorders, particularly affecting immune cell function.

Are there therapeutic implications or potential targets related to CXCR4 in diseases involving immune dysregulation and inflammation?

There are potential therapeutic implications related to CXCR4 in diseases involving immune dysregulation and inflammation, making it a target for drug development.

How does CXCR4 contribute to the regulation of inflammatory responses and immune cell trafficking in various tissues?

CXCR4 contributes to the regulation of inflammatory responses and immune cell trafficking in various tissues, influencing the outcome of immune reactions.

What is the primary function of C-X-C chemokine receptor type 4 (CXCR4) in cellular processes and immune responses?

C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in cellular processes, primarily contributing to immune responses and cell migration.