Recombinant Human CYP2A6 Protein, Flag-tagged

• Cat.No.: CYP2A6-01H
• Product Overview: Recombinant protein from the full-length sequence of Homo sapiens cytochrome P450 family 2 subfamily A member 6 (CYP2A6) (NM_000762), with a DYKDDDDK tag was expressed in Human Cells.

Specification

• Description: This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.
• Source: Human Cells
• Species: Human
• Tag: DYKDDDDK
• Molecular Mass: 56.3 kDa
• Endotoxin: Endotoxin level is < 0.1 ng/μg of protein (<1EU /μg)
• Purity: > 90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
• Storage Buffer: Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives

Gene Information

• Gene Name: CYP2A6 cytochrome P450 family 2 subfamily A member 6 [ Homo sapiens (human) ]
• Official Symbol: CYP2A6
• Synonyms: CYP2A6; cytochrome P450 family 2 subfamily A member 6; CPA6; CYP2A; CYP2A3; P450PB; CYPIIA6; P450C2A; cytochrome P450 2A6; 1,4-cineole 2-exo-monooxygenase; coumarin 7-hydroxylase; cytochrome P450 IIA3; cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; flavoprotein-linked monooxygenase; xenobiotic monooxygenase; EC 1.14.14.1
• Gene ID: 1548
• mRNA Refseq: NM_000762
• Protein Refseq: NP_000753
• MIM: 122720
• UniProt ID: P11509