Recombinant Human DAG1

• Cat.No.: DAG1-26240TH
• Product Overview: Recombinant fragment of Human DAG1 with proprietary tag.

Specification

• Description: Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
• Protein length: 110 amino acids
• Molecular Weight: 37.730kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Expressed in a variety of fetal and adult tissues. In epidermal tissue, located to the basement membrane. Also expressed in keratinocytes and fibroblasts.
• Biological activity: useful for Antibody Production and Protein Array
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Reduced glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 peptidase S72 domain.

Gene Information

• Gene Name: DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) [ Homo sapiens ]
• Official Symbol: DAG1
• Synonyms: DAG1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystroglycan; 156DAG; A3a; AGRNR; alpha dystroglycan; beta dystroglycan; DAG; dystrophin associated glycoprotein 1
• Gene ID: 1605
• mRNA Refseq: NM_001165928
• Protein Refseq: NP_001159400
• MIM: 128239
• Uniprot ID: Q14118
• Chromosome Location: 3p21
• Pathway: Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; ECM-receptor interaction, organism-specific biosystem
• Function: SH2 domain binding; actin binding; alpha-actinin binding; calcium ion binding; laminin-1 binding

Reviews

08/17/2022

By utilizing the DAG1 protein in my experiments, I can trust that I am working with a product of the highest caliber, backed by a company dedicated to delivering exceptional quality and support.

01/23/2022

The reliability and reproducibility of the DAG1 Protein's performance make it a go-to option for WB experiments.

03/12/2021

The DAG1 protein is of exceptional quality and will undoubtedly meet my experimental needs with utmost reliability and accuracy.

Q&As

Are there any specific animal models used to study DAG1-related muscle disorders?

Yes, mouse models with mutations in the DAG1 gene are commonly used to study the pathophysiology of DAG1-related muscle disorders.

What are the symptoms of DAG1-related muscle disorders?

Symptoms can include muscle weakness, hypotonia, and developmental delay, as well as eye and brain abnormalities in some cases.

How does DAG1 protein contribute to the stability of muscle cell membranes?

DAG1 protein forms a complex with other proteins and glycoproteins to anchor the muscle cell membrane to the extracellular matrix.

Can DAG1 protein be used as a biomarker for muscle disorders?

Studies are exploring the potential use of DAG1 protein levels as a diagnostic and prognostic biomarker for muscle disorders.

How does DAG1 protein interact with other proteins in the muscle cell membrane?

DAG1 protein forms a complex with dystrophin, sarcoglycans, and other proteins to maintain the stability of the muscle cell membrane.