Recombinant Human DCAF7, His-tagged

• Cat.No.: DCAF7-30698TH
• Product Overview: Recombinant fragment of Human WDR68 with an N terminal His tag; 298aa, 33.6kDa inclusive of tag.

Specification

• Description: The WD-repeat protein is encoded by the DCAF7 protein, it is 53% identical to the petunia An11 protein and is conserved in worms and yeast, which do not produce anthocyanins.
• Protein length: 277 amino acids
• Conjugation: HIS
• Molecular Weight: 33.600kDa
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.02% DTT, 2.4% Urea
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMVYAM NWSVRPDKRFRLALGSFVEEYNNKV QLVGLDEESSEFICRNTFDHPYPTT KLMWIPDTKGVYPDLLATSGDYLRV WRVGETETRLECLLNNNKNSDFCAP LTSFDWNEVDPYLLGTSSIDTTCTI WGLETGQVLGRVNLVSGHVKTQLIA HDKEVYDIAFSRAGGGRDMFASVGA DGSVRMFDLRHLEHSTIIYEDPQHH PLLRLCWNKQDPNYLATMAMDGMEV VILDVRVPCTPVARLNNHRACVNGI AWAPHSSCHICTAADDHQALIWD
• Sequence Similarities: Belongs to the WD repeat DCAF7 family.Contains 4 WD repeats.

Gene Information

• Gene Name: DCAF7 DDB1 and CUL4 associated factor 7 [ Homo sapiens ]
• Official Symbol: DCAF7
• Synonyms: DCAF7; DDB1 and CUL4 associated factor 7; WD repeat domain 68 , WDR68; DDB1- and CUL4-associated factor 7; HAN11; human anthocyanin; seven WD repeat protein of the AN11 family 1; SWAN 1
• Gene ID: 10238
• mRNA Refseq: NM_005828
• Protein Refseq: NP_005819
• MIM: 605973
• Uniprot ID: P61962
• Chromosome Location: 17q23.3
• Pathway: TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem
• Function: protein binding

Reviews

09/06/2020

The DCAF7 protein is a top-quality product that is sure to fulfill my experimental requirements.

05/02/2019

It has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.

11/02/2016

the ease of use and compatibility of the DCAF7 protein with various techniques further enhances its appeal.

Q&As

How does DCAF7 protein contribute to the development of drug resistance in cancer?

DCAF7 protein has been implicated in promoting drug resistance in cancer cells by affecting DNA repair pathways, making it an important factor in cancer treatment resistance.

Are there any known genetic alterations in the DCAF7 gene associated with cancer susceptibility?

While specific genetic alterations in the DCAF7 gene have not been extensively studied, it is possible that mutations or dysregulation of the gene may contribute to cancer susceptibility.

Is there any evidence linking DCAF7 protein to specific types of cancer?

Research has suggested that DCAF7 protein may be involved in the development of various types of cancer, including breast, ovarian, and colorectal cancer.

How is the expression of DCAF7 protein assessed in clinical settings?

The expression of DCAF7 protein can be assessed using immunohistochemistry or molecular techniques, which may provide valuable information for cancer prognosis and treatment planning.

Can targeting DCAF7 protein have potential implications for personalized cancer therapy?

Targeting DCAF7 protein may have implications for personalized cancer therapy by exploiting specific vulnerabilities in cancer cells related to DNA repair mechanisms.