Description : |
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
100.9 kDa |
AA Sequence : |
MGPEALSSLLLLLLVASGDADMKGH FDPAKCRYALGMQDRTIPDSDISAS SSWSDSTAARHSRLESSDGDGAWCP AGSVFPKEEEYLQVDLQRLHLVALV GTQGRHAGGLGKEFSRSYRLRYSRD GRRWMGWKDRWGQEVISGNEDPEGV VLKDLGPPMVARLVRFYPRADRVMS VCLRVELYGCLWRDGLLSYTAPVGQ TMYLSEAVYLNDSTYDGHTVGGLQY GGLGQLADGVVGLDDFRKSQELRVW PGYDYVGWSNHSFSSGYVEMEFEFD RLRAFQAMQVHCNNMHTLGARLPGG VECRFRRGPAMAWEGEPMRHNLGGN LGDPRARAVSVPLGGRVARFLQCRF LFAGPWLLFSEISFISDVVNNSSPA LGGTFPPAPWWPPGPPPTNFSSLEL EPRGQQPVAKAEGSPTAILIGCLVA IILLLLLIIALMLWRLHWRRLLSKA ERRVLEEELTVHLSVPGDTILINNR PGPREPPPYQEPRPRGNPPHSAPCV PNGSALLLSNPAYRLLLATYARPPR GPGPPTPAWAKPTNTQAYSGDYMEP EKPGAPLLPPPPQNSVPHYAEADIV TLQGVTGGNTYAVPALPPGAVGDGP PRVDFPRSRLRFKEKLGEGQFGEVH LCEVDSPQDLVSLDFPLNVRKGHPL LVAVKILRPDATKNARNDFLKEVKI MSRLKDPNIIRLLGVCVQDDPLCMI TDYMENGDLNQFLSAHQLEDKAAEG APGDGQAAQGPTISYPMLLHVAAQI ASGMRYLATLNFVHRDLATRNCLVG ENFTIKIADFGMSRNLYAGDYYRVQ GRAVLPIRWMAWECILMGKFTTASD VWAFGVTLWEVLMLCRAQPFGQLTD EQVIENAGEFFRDQGRQVYLSRPPA CPQGLYELMLRCWSRESEQRPPFSQ LHRFLAEDALNTVTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |