Recombinant Human Dehydrogenase/Reductase (SDR Family) Member 9, His-tagged
Cat.No. : | DHRS9-1561H |
Product Overview : | Recombinant human DHRS9 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
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Cat. No. : | DHRS9-1561H |
Description : | DHRS9, also known as dehydrogenase/reductase SDR family member 9, functions as a homotetramer that converts both 3-alpha-tetrahydroprogesterone (allopregnanolone) and 3-alpha-androstanediol to dihydroxyprogesterone and is thought to play a role in retinoic acid biosynthesis. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 2mM DTT, 0.1mM PMSF. |
Molecular Weight : | 35.9 kDa (327aa), confirmed by MALDI-TOF. |
Purity : | >90% by SDS-PAGE |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MGSHMRKGKL KIEDITDKYI FITGCDSGFG NLAARTFDKK GFHVIAACLT ESGSTALKAE TSERLRTVLLDVTDPENVKR TAQWVKNQVG EKGLWGLINN AGVPGVLAPT DWLTLEDYRE PIEVNLFGLI SVTLNMLPLV KKAQGRVINV SSVGGRLAIVGGGYTPSKYA VEGFNDSLRR DMKAFGVHVS CIEPGLFKTN LADPVKVIEK KLAIWEQLSP DIKQQYGEGY IEKSLDKLKG NKSYVNMDLSPVVECMDHAL TSLFPKTHYA AGKDAKIFWI PLSHMPAALQ DFLLLKQKAE LANPKAV |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | Metabolic pathways; Retinol metabolism |
Gene Name : | DHRS9 dehydrogenase/reductase (SDR family) member 9 [ Homo sapiens ] |
Official Symbol : | DHRS9 |
Synonyms : | DHRS9; dehydrogenase/reductase (SDR family) member 9; RDHL; RDH15; RDHTBE; SDR9C4; RETSDR8; 3ALPHA-HSD; 3-alpha-HSD; OTTHUMP00000163043; OTTHUMP00000204923; OTTHUMP00000204925; OTTHUMP00000204926; OTTHUMP00000205057; retinol dehydrogenase homolog; 3-alpha hydroxysteroid dehydrogenase; short-chain dehydrogenase/reductase retSDR8; NADP-dependent retinol dehydrogenase/reductase; short chain dehydrogenase/reductase family 9C, member 4; 3alpha-HSD; dehydrogenase/reductase SDR family member 9; EC 1.1; RDH-E2; EC 1.1.1; EC 1.1.1.105 |
Gene ID : | 10170 |
mRNA Refseq : | NM_001142270 |
Protein Refseq : | NP_001135742 |
MIM : | 612131 |
UniProt ID : | Q9BPW9 |
Chromosome Location : | 2q31.1 |
Function : | alcohol dehydrogenase (NAD) activity; binding NAS PubMed; retinol dehydrogenase activity; testosterone dehydrogenase (NAD+) activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere is currently no definitive way to alter the variation of the DHRS9 gene. However, healthy lifestyles, such as a balanced diet, moderate exercise, and good social interactions, may help reduce the risk of neurological disorders, although they may not directly improve the effects of the DHRS9 gene variant.
Mutations in the DHRS9 gene may cause abnormal function of retinoic acid-binding protein 1, which in turn affects retinoic acid metabolism and may increase the risk of neurological diseases.
Studies have shown that mutations in the DHRS9 gene may affect cognitive function, but the specific mechanism still needs further research.
Future research on the DHRS9 gene may involve more in-depth studies of molecular mechanisms, disease associations, and the development of therapeutics for this gene variant.
Studies have shown that mutations in the DHRS9 gene may be associated with certain behavioral traits, such as social skills, attention, and impulse control.
Variants in the DHRS9 gene, including single nucleotide polymorphisms (SNPs), insertions/deletions, etc., can be detected by gene sequencing technology.
Customer Reviews (3)
Write a reviewDHRS9 is highly specific and active, and does not cause abnormal immune responses.
The product is very mature and can be used for scientific research.
The solubility is very good and can be easily dissolved in a variety of buffers.
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