Recombinant Human Deoxyribonuclease I-like 3

• Cat.No.: DNASE1L3-622H
• Product Overview: Recombinant Human Deoxyribonuclease I-like 3 is produced inE. coli.

Specification

• Cat. No.: DNASE1L3-622H
• Description: Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene. This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
• Source: E. coli.
• Purity: ≥90% (SDS-PAGE).
• Formulation: Liquid. In 25mM TRIS-HCl, pH 7.5, containing 150mM potassium chloride and 50% glycerol.
• Application: For studying DNAS1L3 catalyzed oligonucleosomal DNA fragmentation.
• Storage And Stability: Stable for at least 6 months after receipt when stored at -80°C.

Gene Information

• Gene Name: DNASE1L3 deoxyribonuclease I-like 3 [ Homo sapiens ]
• Synonyms: DNASE1L3; deoxyribonuclease I-like 3; DNase I homolog protein 2; DNase I homolog protein DHP2; DNase I-like 3; DNase gamma; LS-DNase; Liver and spleen DNase; deoxyribonuclease I-like III; deoxyribonuclease gamma; DHP2, DNAS1L3; EC 3.1.21.-
• Gene ID: 1776
• mRNA Refseq: NM_004944
• Protein Refseq: NP_004935
• MIM: 602244
• UniProt ID: Q13609
• Chromosome Location: 3p21.1-p14.3
• Function: DNA binding; calcium ion binding; deoxyribonuclease activity; endodeoxyribonuclease activity; hydrolase activity

Reviews

01/30/2023

The proteins accepted were of very high purity and were put into experiments with satisfactory results.

04/01/2022

Fast and timely shipment helped me to get satisfactory experimental results in short time.

07/21/2021

Excellent after-sales service, solving many experimental problems.

Q&As

What biological processes are DNASE1L3 involved in?

DNASE1L3 plays an important role in cell apoptosis and cell necrosis.

What does DNASE1L3 have to do with NET?

DNASE1L3 interacts with NET.

What diseases has DNASE1L3 been linked to studies of?

DNASE1L3 has been associated with the study of diseases such as hepatocellular carcinoma, gastric adenocarcinoma and colon cancer.

How does DNASE1L3 affect the development of hepatocellular carcinoma?

DNASE1L3 inhibits hepatocellular carcinoma progression by delaying cell cycle progression and attenuating glycolysis in hepatocellular carcinoma.