Recombinant Human DFFA protein, GST-tagged
Cat.No. : | DFFA-30138H |
Product Overview : | Recombinant Human DFFA (8-328 aa) protein, fused to GST tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. |
Protein length : | Gly8-Gln328 |
AA Sequence : | GVPESGEIRTLKPCLLRRNYSREQH GVAASCLEDLRSKACDILAIDKSLT PVTLVLAEDGTIVDDDDYFLCLPSN TKFVALASNEKWAYNNSDGGTAWIS QESFDVDETDSGAGLKWKNVARQLK EDLSSIILLSEEDLQMLVDAPCSDL AQELRQSCATVQRLQHTLQQVLDQR EEVRQSKQLLQLYLQALEKEGSLLS KQEESKAAFGEEVDAVDTGISRETS SDVALASHILTALREKQAPELSLSS QDLELVTKEDPKALAVALNWDIKKT ETVQEACERELALRLQQTQSLHSLR SISASKASPPGDLQNPKRARQ |
Purity : | 90%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Stability : | Store for up to 12 months at -20°C to -80°C as lyophilized powder. |
Storage : | Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. |
Gene Name : | DFFA DNA fragmentation factor subunit alpha [ Homo sapiens (human) |
Official Symbol : | DFFA |
Synonyms : | DFFA; DFF1; ICAD; DFF-45 |
Gene ID : | 1676 |
mRNA Refseq : | NM_004401 |
Protein Refseq : | NP_004392 |
MIM : | 601882 |
UniProt ID : | O00273 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionDysregulation or abnormal expression of DFFA is associated with various conditions, including cancer and neurodegenerative disorders, highlighting its role in apoptotic dysfunction.
DFFA contributes to DNA fragmentation and chromatin condensation by being cleaved and activated by caspases, particularly caspase-3, during apoptotic cell death.
DFFA is predominantly localized in the nucleus, specifically during the initiation of apoptosis, where it actively participates in chromatin condensation and DNA fragmentation.
There are potential therapeutic implications related to DFFA in diseases involving apoptotic dysregulation and abnormal cell survival, making it a target for drug development.
DNA Fragmentation Factor Subunit Alpha (DFFA) plays a crucial role in cellular processes, primarily contributing to the execution of apoptosis and programmed cell death.
DFFA actively participates in regulating the balance between cell survival and programmed cell death in various tissues, influencing tissue homeostasis.
Specific caspases, including caspase-3, activate DFFA, influencing its role in the execution phase of apoptosis and facilitating efficient DNA degradation.
Customer Reviews (3)
Write a reviewWe felt well-supported throughout our usage of the product, thanks to the dedicated customer service.
Consistency in the product's behavior across experimental conditions enhanced the credibility of our findings.
The product's adaptability to various buffers contributed to its stable and reliable performance.
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