Recombinant Human DHODH, His-tagged
Cat.No. : | DHODH-11969H |
Product Overview : | Recombinant Human DHODH protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 1-395a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | DHODH dihydroorotate dehydrogenase (quinone) [ Homo sapiens ] |
Official Symbol : | DHODH |
Synonyms : | DHODH; dihydroorotate dehydrogenase (quinone); dihydroorotate dehydrogenase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate oxidase; human complement of yeast URA1; URA1; POADS; DHOdehase; |
Gene ID : | 1723 |
mRNA Refseq : | NM_001361 |
Protein Refseq : | NP_001352 |
MIM : | 126064 |
UniProt ID : | Q02127 |
Chromosome Location : | 16q22 |
Pathway : | Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Pyrimidine biosynthesis, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem; Pyrimidine metabolism, conserved biosystem; |
Function : | dihydroorotate dehydrogenase activity; dihydroorotate dehydrogenase activity; dihydroorotate oxidase activity; oxidoreductase activity; |
Products Types
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DHODH-1517R | Recombinant Rat DHODH Protein, His (Fc)-Avi-tagged | +Inquiry |
DHODH-2590H | Recombinant Human DHODH Protein, GST-tagged | +Inquiry |
DHODH-2355M | Recombinant Mouse DHODH Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DHODH-6944HCL | Recombinant Human DHODH 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIt catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.
DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.
DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.
DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.
Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.
Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.
Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.
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