Recombinant Human DHPS, His-tagged
Cat.No. : | DHPS-26684TH |
Product Overview : | Recombinant full length Human DHPS with a N terminal His tag. 389 amino acids with a predicted MWt 43.1 kDa including tag. |
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Description : | This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Protein length : | 369 amino acids |
Conjugation : | HIS |
Molecular Weight : | 43.100kDa inclusive of tags |
Source : | E. coli |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | pH: 8.00Constituents:0.32% Tris HCl, 0.58% Sodium chloride, 20% Glycerol |
Storage : | Please see Notes section |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MEGSLEREAP AGALAAVLKH SSTLPPESTQ VRGYDFNRGV NYRALLEAFG TTGFQATNFG RAVQQVNAMI EKKLEPLSQD EDQHADLTQS RRPLTSCTIF LGYTSNLISS GIRETIRYLV QHNMVDVLVT TAGGVEEDLI KCLAPTYLGE FSLRGKELRE NGINRIGNLL VPNENYCKFE DWLMPILDQM VMEQNTEGVK WTPSKMIARL GKEINNPESV YYWAQKNHIP VFSPALTDGS LGDMIFFHSY KNPGLVLDIV EDLRLINTQA IFAKCTGMII LGGGVVKHHI ANANLMRNGA DYAVYINTAQ EFDGSDSGAR PDEAVSWGKI RVDAQPVKVY ADASLVFPLL VAETFAQKMD AFMHEKNED |
Sequence Similarities : | Belongs to the deoxyhypusine synthase family. |
Gene Name : | DHPS deoxyhypusine synthase [ Homo sapiens ] |
Official Symbol : | DHPS |
Synonyms : | DHPS; deoxyhypusine synthase; MIG13; migration inducing gene 13; |
Gene ID : | 1725 |
mRNA Refseq : | NM_001206974 |
Protein Refseq : | NP_001193903 |
MIM : | 600944 |
Uniprot ID : | P49366 |
Chromosome Location : | 19p13.2 |
Pathway : | Hypusine synthesis from eIF5A-lysine, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Post-translational modification: gamma carboxylation and hypusine formation, organism-specific biosystem; Post-translational protein modification, organism-specific biosystem; hypusine biosynthesis, conserved biosystem; |
Function : | deoxyhypusine synthase activity; protein binding; transferase activity; |
Products Types
◆ Recombinant Protein | ||
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DHPS-2592H | Recombinant Human DHPS Protein, GST-tagged | +Inquiry |
DHPS-2356M | Recombinant Mouse DHPS Protein, His (Fc)-Avi-tagged | +Inquiry |
DHPS-1518R | Recombinant Rat DHPS Protein, His (Fc)-Avi-tagged | +Inquiry |
DHPS-1078R | Recombinant Rhesus Macaque DHPS Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DHPS-6942HCL | Recombinant Human DHPS 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, bacterial resistance to sulfonamides can arise due to mutations in DHPS that reduce the drug's binding affinity.
Yes, mutations in DHPS can lead to reduced effectiveness of sulfonamides, contributing to antibiotic resistance.
DHPS mutations have been associated with resistance to sulfadoxine-pyrimethamine, a drug used to prevent and treat malaria.
Sulfonamides are used to treat urinary tract infections, respiratory tract infections, and other bacterial infections.
DHPS has potential as a target for developing new antiparasitic drugs due to its role in folate biosynthesis in parasites such as Plasmodium.
Customer Reviews (3)
Write a reviewTheir expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.
Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.
The DHPS protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.
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