Recombinant Human DICER1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | DICER1-1088H |
Product Overview : | DICER1 MS Standard C13 and N15-labeled recombinant protein (NP_803187) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 218.5 kDa |
AA Sequence : | MKSPALQPLSMAGLQLMTPASSPMG PFFGLPWQQEAIHDNIYTPRKYQVE LLEAALDHNTIVCLNTGSGKTFIAV LLTKELSYQIRGDFSRNGKRTVFLV NSANQVAQQVSAVRTHSDLKVGEYS NLEVNASWTKERWNQEFTKHQVLIM TCYVALNVLKNGYLSLSDINLLVFD ECHLAILDHPYREIMKLCENCPSCP RILGLTASILNGKCDPEELEEKIQK LEKILKSNAETATDLVVLDRYTSQP CEIVVDCGPFTDRSGLYERLLMELE EALNFINDCNISVHSKERDSTLISK QILSDCRAVLVVLGPWCADKVAGMM VRELQKYIKHEQEELHRKFLLFTDT FLRKIHALCEEHFSPASLDLKFVTP KVIKLLEILRKYKPYERQQFESVEW YNNRNQDNYVSWSDSEDDDEDEEIE EKEKPETNFPSPFTNILCGIIFVER RYTAVVLNRLIKEAGKQDPELAYIS SNFITGHGIGKNQPRNKQMEAEFRK QEEVLRKFRAHETNLLIATSIVEEG VDIPKCNLVVRFDLPTEYRSYVQSK GRARAPISNYIMLADTDKIKSFEED LKTYKAIEKILRNKCSKSVDTGETD IDPVMDDDDVFPPYVLRPDDGGPRV TINTAIGHINRYCARLPSDPFTHLA PKCRTRELPDGTFYSTLYLPINSPL RASIVGPPMSCVRLAERVVALICCE KLHKIGELDDHLMPVGKETVKYEEE LDLHDEEETSVPGRPGSTKRRQCYP KAIPECLRDSYPRPDQPCYLYVIGM VLTTPLPDELNFRRRKLYPPEDTTR CFGILTAKPIPQIPHFPVYTRSGEV TISIELKKSGFMLSLQMLELITRLH QYIFSHILRLEKPALEFKPTDADSA YCVLPLNVVNDSSTLDIDFKFMEDI EKSEARIGIPSTKYTKETPFVFKLE DYQDAVIIPRYRNFDQPHRFYVADV YTDLTPLSKFPSPEYETFAEYYKTK YNLDLTNLNQPLLDVDHTSSRLNLL TPRHLNQKGKALPLSSAEKRKAKWE SLQNKQILVPELCAIHPIPASLWRK AVCLPSILYRLHCLLTAEELRAQTA SDAGVGVRSLPADFRYPNLDFGWKK SIDSKSFISISNSSSAENDNYCKHS TIVPENAAHQGANRTSSLENHDQMS VNCRTLLSESPGKLHVEVSADLTAI NGLSYNQNLANGSYDLANRDFCQGN QLNYYKQEIPVQPTTSYSIQNLYSY ENQPQPSDECTLLSNKYLDGNANKS TSDGSPVMAVMPGTTDTIQVLKGRM DSEQSPSIGYSSRTLGPNPGLILQA LTLSNASDGFNLERLEMLGDSFLKH AITTYLFCTYPDAHEGRLSYMRSKK VSNCNLYRLGKKKGLPSRMVVSIFD PPVNWLPPGYVVNQDKSNTDKWEKD EMTKDCMLANGKLDEDYEEEDEEEE SLMWRAPKEEADYEDDFLEYDQEHI RFIDNMLMGSGAFVKKISLSPFSTT DSAYEWKMPKKSSLGSMPFSSDFED FDYSSWDAMCYLDPSKAVEEDDFVV GFWNPSEENCGVDTGKQSISYDLHT EQCIADKSIADCVEALLGCYLTSCG ERAAQLFLCSLGLKVLPVIKRTDRE KALCPTRENFNSQQKNLSVSCAAAS VASSRSSVLKDSEYGCLKIPPRCMF DHPDADKTLNHLISGFENFEKKINY RFKNKAYLLQAFTHASYHYNTITDC YQRLEFLGDAILDYLITKHLYEDPR QHSPGVLTDLRSALVNNTIFASLAV KYDYHKYFKAVSPELFHVIDDFVQF QLEKNEMQGMDSELRRSEEDEEKEE DIEVPKAMGDIFESLAGAIYMDSGM SLETVWQVYYPMMRPLIEKFSANVP RSPVRELLEMEPETAKFSPAERTYD GKVRVTVEVVGKGKFKGVGRSYRIA KSAAARRALRSLKANQPQVPNSTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | DICER1 dicer 1, ribonuclease III [ Homo sapiens (human) ] |
Official Symbol : | DICER1 |
Synonyms : | DICER1; dicer 1, ribonuclease type III; Dicer1, Dcr 1 homolog (Drosophila); endoribonuclease Dicer; Dicer; dicer 1; double stranded RNA specific endoribonuclease; HERNA; K12H4.8 LIKE; KIAA0928; K12H4.8-LIKE; helicase MOI; helicase-moi; Dicer1, Dcr-1 homolog; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease; DCR1; MNG1; |
Gene ID : | 23405 |
mRNA Refseq : | NM_177438 |
Protein Refseq : | NP_803187 |
MIM : | 606241 |
UniProt ID : | Q9UPY3 |
Products Types
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDICER1 mutations may also lead to non-cancer conditions, such as pleuropulmonary blastoma syndrome and cystic nephroma.
Research is ongoing to explore whether targeting DICER1-related pathways could lead to novel cancer treatments.
Yes, some diagnostic tests can measure DICER1 expression, which may be relevant in certain cancer types.
Yes, DICER1 mutations can be passed down through families and cause a hereditary predisposition to certain cancers.
DICER1 mutations or dysregulation can lead to abnormal microRNA processing, contributing to the development of cancer.
Customer Reviews (3)
Write a reviewIts purity and functional integrity guarantee optimal performance in a wide range of experimental applications.
Their team of experts is readily available to assist you with any inquiries or challenges you may encounter during your experiments.
This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.
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