Recombinant Human DMP1 Protein, GST-tagged
Cat.No. : | DMP1-2706H |
Product Overview : | Human DMP1 partial ORF ( NP_004398.1, 221 a.a. - 330 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 37.84 kDa |
AA Sequence : | ESIRSERGNSRMNSAGMKSKESGEN SEQANTQDSGGSQLLEHPSRKIFRK SRISEEDDRSELDDNNTMEEVKSDS TENSNSRDTGLSQPRRDSKGDSQED SKENLSQEES |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | DMP1 dentin matrix acidic phosphoprotein 1 [ Homo sapiens ] |
Official Symbol : | DMP1 |
Synonyms : | DMP1; dentin matrix acidic phosphoprotein 1; dentin matrix acidic phosphoprotein; dentin matrix protein 1; ARHP; ARHR; DMP-1; |
Gene ID : | 1758 |
mRNA Refseq : | NM_001079911 |
Protein Refseq : | NP_001073380 |
MIM : | 600980 |
UniProt ID : | Q13316 |
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◆ Lysates | ||
DMP1-1977HCL | Recombinant Human DMP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, targeting DMP1 in drug development may offer new avenues for treating conditions related to bone and dentin abnormalities.
Research suggests that DMP1 may have therapeutic potential in promoting bone regeneration and treating conditions like osteoporosis.
DMP1 is involved in the repair and remodeling of bone tissue after fractures by influencing the mineralization and structural integrity of the newly formed bone.
DMP1 levels can be measured in biological samples, such as blood or saliva, to assess the potential presence of dental or skeletal disorders and to monitor disease progression.
Some studies suggest that DMP1 may play a role in maintaining the health of periodontal tissues, and alterations in its expression could be associated with periodontal disease.
Customer Reviews (3)
Write a reviewThis commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.
The DMP1 protein offers numerous advantages in trials and research experiments.
Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.
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