Recombinant Human DNM2 Protein, GST-tagged

• Cat.No.: DNM2-2786H
• Product Overview: Human DNM2 full-length ORF ( NP_001005360.1, 1 a.a. - 870 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 124.5 kDa
• AA Sequence: MGNRGMEELIPLVNKLQDAFSSIGQ SCHLDLPQIAVVGGQSAGKSSVLEN FVGRDFLPRGSGIVTRRPLILQLIF SKTEHAEFLHCKSKKFTDFDEVRQE IEAETDRVTGTNKGISPVPINLRVY SPHVLNLTLIDLPGITKVPVGDQPP DIEYQIKDMILQFISRESSLILAVT PANMDLANSDALKLAKEVDPQGLRT IGVITKLDLMDEGTDARDVLENKLL PLRRGYIGVVNRSQKDIEGKKDIRA ALAAERKFFLSHPAYRHMADRMGTP HLQKTLNQQLTNHIRESLPALRSKL QSQLLSLEKEVEEYKNFRPDDPTRK TKALLQMVQQFGVDFEKRIEGSGDQ VDTLELSGGARINRIFHERFPFELV KMEFDEKDLRREISYAIKNIHGVRT GLFTPDLAFEAIVKKQVVKLKEPCL KCVDLVIQELINTVRQCTSKLSSYP RLREETERIVTTYIREREGRTKDQI LLLIDIEQSYINTNHEDFIGFANAQ QRSTQLNKKRAIPNQGEILVIRRGW LTINNISLMKGGSKEYWFVLTAESL SWYKDEEEKEKKYMLPLDNLKIRDV EKGFMSNKHVFAIFNTEQRNVYKDL RQIELACDSQEDVDSWKASFLRAGV YPEKDQAENEDGAQENTFSMDPQLE RQVETIRNLVDSYVAIINKSIRDLM PKTIMHLMINNTKAFIHHELLAYLY SSADQSSLMEESADQAQRRDDMLRM YHALKEALNIIGDISTSTVSTPVPP PVDDTWLQSASSHSPTPQRRPVSSI HPPGRPPAVRGPTPGPPLIPVPVGA AASFSAPPIPSRPGPQSVFANSDLF PAPPQIPSRPVRIPPGIPPGVPSRR PPAAPSRPTIIRPAEPSLLD
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DNM2 dynamin 2 [ Homo sapiens ]
• Official Symbol: DNM2
• Synonyms: DNM2; dynamin 2; dynamin-2; CMTDI1; CMTDIB; cytoskeletal protein; DI CMTB; DYN2; dynamin II; DYNII; CMT2M; DI-CMTB
• Gene ID: 1785
• mRNA Refseq: NM_001005360
• Protein Refseq: NP_001005360
• MIM: 602378
• UniProt ID: P50570