Recombinant Human DNMT3B Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | DNMT3B-4643H |
Product Overview : | DNMT3B MS Standard C13 and N15-labeled recombinant protein (NP_008823) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 95.8 kDa |
AA Sequence : | MKGDTRHLNGEEDAGGREDSILVNG ACSDQSSDSPPILEAIRTPEIRGRR SSSRLSKREVSSLLSYTQDLTGDGD GEDGDGSDTPVMPKLFRETRTRSES PAVRTRNNNSVSSRERHRPSPRSTR GRQGRNHVDESPVEFPATRSLRRRA TASAGTPWPSPPSSYLTIDLTDDTE DTHGTPQSSSTPYARLAQDSQQGGM ESPQVEADSGDGDSSEYQDGKEFGI GDLVWGKIKGFSWWPAMVVSWKATS KRQAMSGMRWVQWFGDGKFSEVSAD KLVALGLFSQHFNLATFNKLVSYRK AMYHALEKARVRAGKTFPSSPGDSL EDQLKPMLEWAHGGFKPTGIEGLKP NNTQPVVNKSKVRRAGSRKLESRKY ENKTRRRTADDSATSDYCPAPKRLK TNCYNNGKDRGDEDQSREQMASDVA NNKSSLEDGCLSCGRKNPVSFHPLF EGGLCQTCRDRFLELFYMYDDDGYQ SYCTVCCEGRELLLCSNTSCCRCFC VECLEVLVGTGTAAEAKLQEPWSCY MCLPQRCHGVLRRRKDWNVRLQAFF TSDTGLEYEAPKLYPAIPAARRRPI RVLSLFDGIATGYLVLKELGIKVGK YVASEVCEESIAVGTVKHEGNIKYV NDVRNITKKNIEEWGPFDLVIGGSP CNDLSNVNPARKGLYEGTGRLFFEF YHLLNYSRPKEGDDRPFFWMFENVV AMKVGDKRDISRFLECNPVMIDAIK VSAAHRARYFWGNLPGMNRPVIASK NDKLELQDCLEYNRIAKLKKVQTIT TKSNSIKQGKNQLFPVVMNGKEDVL WCTELERIFGFPVHYTDVSNMGRGA RQKLLGRSWSVPVIRHLFAPLKDYF ACETRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | DNMT3B DNA methyltransferase 3 beta [ Homo sapiens (human) ] |
Official Symbol : | DNMT3B |
Synonyms : | DNMT3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; ICF; ICF1; M.HsaIIIB; |
Gene ID : | 1789 |
mRNA Refseq : | NM_006892 |
Protein Refseq : | NP_008823 |
MIM : | 602900 |
UniProt ID : | Q9UBC3 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTargeting DNMT3B for therapeutic purposes may lead to off-target effects and unintended changes in DNA methylation, potentially causing adverse effects on normal cellular function and gene expression.
Yes, mutations in the DNMT3B gene are linked to a rare genetic disorder called ICF (Immunodeficiency, Centromeric instability, Facial anomalies) syndrome, characterized by immune system deficiencies, facial abnormalities, and unstable centromeric regions in chromosomes.
Research has shown that alterations in DNMT3B expression or activity can be associated with various types of cancer, making it a potential biomarker for cancer diagnosis, prognosis, and treatment response.
DNMT3B plays a crucial role in establishing de novo DNA methylation patterns during embryonic development and cell differentiation, contributing to the epigenetic regulation of gene expression.
Inhibition of DNMT3B activity through targeted therapy or epigenetic modifying agents has been explored as a potential treatment strategy to reverse abnormal DNA methylation patterns and restore normal gene expression in cancer cells.
Customer Reviews (3)
Write a reviewThe DNMT3B protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.
With its consistent and outstanding results, the DNMT3B protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.
Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.
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