Recombinant Human DPP3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: DPP3-6457H
• Product Overview: DPP3 MS Standard C13 and N15-labeled recombinant protein (NP_569710) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 82.6 kDa
• AA Sequence: MADTQYILPNDIGVSSLDCREAFRL LSPTERLYAYHLSRAAWYGGLAVLL QTSPEAPYIYALLSRLFRAQDPDQL RQHALAEGLTEEEYQAFLVYAAGVY SNMGNYKSFGDTKFVPNLPKEKLER VILGSEAAQQHPEEVRGLWQTCGEL MFSLEPRLRHLGLGKEGITTYFSGN CTMEDAKLAQDFLDSQNLSAYNTRL FKEVDGEGKPYYEVRLASVLGSEPS LDSEVTSKLKSYEFRGSPFQVTRGD YAPILQKVVEQLEKAKAYAANSHQG QMLAQYIESFTQGSIEAHKRGSRFW IQDKGPIVESYIGFIESYRDPFGSR GEFEGFVAVVNKAMSAKFERLVASA EQLLKELPWPPTFEKDKFLTPDFTS LDVLTFAGSGIPAGINIPNYDDLRQ TEGFKNVSLGNVLAVAYATQREKLT FLEEDDKDLYILWKGPSFDVQVGLH ELLGHGSGKLFVQDEKGAFNFDQET VINPETGEQIQSWYRSGETWDSKFS TIASSYEECRAESVGLYLCLHPQVL EIFGFEGADAEDVIYVNWLNMVRAG LLALEFYTPEAFNWRQAHMQARFVI LRVLLEAGEGLVTITPTTGSDGRPD ARVRLDRSKIRSVGKPALERFLRRL QVLKSTGDVAGGRALYEGYATVTDA PPECFLTLRDTVLLRKESRKLIVQP NTRLEGSDVQLLEYEASAAGLIRSF SERFPEDGPELEEILTQLATADARF WKGPSEAPSGQATRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: DPP3 dipeptidyl-peptidase 3 [ Homo sapiens (human) ]
• Official Symbol: DPP3
• Synonyms: DPP3; dipeptidyl-peptidase 3; dipeptidylpeptidase 3, dipeptidylpeptidase III; dipeptidyl peptidase 3; DPP III; dipeptidyl peptidase III; dipeptidyl arylamidase III; dipeptidyl aminopeptidase III; DPPIII; FLJ11387; FLJ22331
• Gene ID: 10072
• mRNA Refseq: NM_130443
• Protein Refseq: NP_569710
• MIM: 606818
• UniProt ID: Q9NY33

Reviews

02/26/2021

Fast delivery, great packaging.

08/01/2020

No issues, worked great.

12/17/2018

Quality better than expected.

Q&As

What role does DPP3 play in metabolic processes?

DPP3 is involved in the final stages of protein catabolism, breaking down small peptides into amino acids, which can then be reused in protein synthesis or participate in various metabolic pathways.

How is DPP3 expression regulated in various tissues?

DPP3 expression varies among tissues, with higher levels in the heart, liver, and kidneys. Its expression is regulated by various factors, including hormonal and metabolic cues.

Are there any known inhibitors targeting DPP3, and what are their therapeutic implications?

Some inhibitors targeting DPP3 have been identified, though their therapeutic implications are still under exploration. Inhibiting DPP3 might be beneficial in conditions where its overactivity contributes to disease pathology.

What is the significance of DPP3 in the context of drug metabolism?

DPP3 is known to metabolize certain drugs, affecting their bioavailability and efficacy. Understanding DPP3's role in drug metabolism can help in drug design and dosage determination.

Are there any known diseases or conditions associated with mutations or dysregulation of DPP3?

Dysregulation of DPP3 has been associated with certain cancers and inflammatory conditions. However, the exact pathological role of DPP3 in these conditions is still under investigation.

What is the primary function of the DPP3 gene and its encoded protein?

The DPP3 gene encodes dipeptidyl peptidase III (DPP3), an intracellular zinc-dependent enzyme. Its primary function is to cleave dipeptides from the N-termini of polypeptides.

How does DPP3 differ from other dipeptidyl peptidases in terms of substrate specificity?

Unlike other dipeptidyl peptidases, DPP3 has a broader substrate specificity, cleaving a variety of dipeptidyl-2-arylamide substrates and playing roles in multiple physiological processes.