Recombinant Human DPYD
Cat.No. : | DPYD-28435TH |
Product Overview : | Recombinant Human DPYD (1a.a. - 173 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ. |
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Description : | The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | Wheat germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 44.66 kDa |
AA Sequence : | MAPVLSKDSADIESILALNPRTQTH ATLCSTSAKKLDKKHWKRNPDKNCF NCEKLENNFDDIKHTTLGERGALRE AMRCLKCADAPCQKSCPTNLDIKSF ITSIANKNYYGAAKMIFSDNPLGLT CGMVCPTSDLCVGGCNLYATEEGPI NIGGLQQFATETLILAFSLMNHL |
Applications : | ELISA; WB-Re; AP; Array |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | DPYD dihydropyrimidine dehydrogenase [ Homo sapiens (human) ] |
Official Symbol : | DPYD |
Synonyms : | DPYD; DHP; DPD; DHPDHASE; dihydropyrimidine dehydrogenase; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrouracil dehydrogenase; dihydrothymine dehydrogenase; NP_000101.2; EC 1.3.1.2; NP_001153773.1 |
Gene ID : | 1806 |
mRNA Refseq : | NM_000110 |
Protein Refseq : | NP_000101 |
MIM : | 612779 |
UniProt ID : | Q12882 |
Chromosome Location : | 1p22 |
Pathway : | Drug metabolism - other enzymes; Pantothenate and CoA biosynthesis; beta-Alanine metabolism |
Function : | 4 iron, 4 sulfur cluster binding; dihydroorotate oxidase activity; dihydropyrimidine dehydrogenase (NADP+) activity |
Products Types
◆ Recombinant Protein | ||
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DPYD-786H | Recombinant Human DPYD Protein, His (Fc)-Avi-tagged | +Inquiry |
DPYD-2860H | Recombinant Human DPYD Protein, GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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