Recombinant Human DPYD Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | DPYD-1291H |
Product Overview : | DPYD MS Standard C13 and N15-labeled recombinant protein (NP_000101) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 111.4 kDa |
AA Sequence : | MAPVLSKDSADIESILALNPRTQTH ATLCSTSAKKLDKKHWKRNPDKNCF NCEKLENNFDDIKHTTLGERGALRE AMRCLKCADAPCQKSCPTNLDIKSF ITSIANKNYYGAAKMIFSDNPLGLT CGMVCPTSDLCVGGCNLYATEEGPI NIGGLQQFATEVFKAMSIPQIRNPS LPPPEKMSEAYSAKIALFGAGPASI SCASFLARLGYSDITIFEKQEYVGG LSTSEIPQFRLPYDVVNFEIELMKD LGVKIICGKSLSVNEMTLSTLKEKG YKAAFIGIGLPEPNKDAIFQGLTQD QGFYTSKDFLPLVAKGSKAGMCACH SPLPSIRGVVIVLGAGDTAFDCATS ALRCGARRVFIVFRKGFVNIRAVPE EMELAKEEKCEFLPFLSPRKVIVKG GRIVAMQFVRTEQDETGKWNEDEDQ MVHLKADVVISAFGSVLSDPKVKEA LSPIKFNRWGLPEVDPETMQTSEAW VFAGGDVVGLANTTVESVNDGKQAS WYIHKYVQSQYGASVSAKPELPLFY TPIDLVDISVEMAGLKFVNPFGLAS ATPATSTSMIRRAFEAGWGFALTKT FSLDKDIVTNVSPRIIRGTTSGPMY GPGQSSFLNIELISEKTAAYWCQSV TELKADFPDNIVIASIMCSYNKNDW TELAKKSEDSGADALELNLSCPHGM GERGMGLACGQDPELVRNICRWVRQ AVQIPFFAKLTPNVTDIVSIARAAK EGGANGVTATNTVSGLMGLKSDGTP WPAVGIAKRTTYGGVSGTAIRPIAL RAVTSIARALPGFPILATGGIDSAE SGLQFLHSGASVLQVCSAIQNQDFT VIEDYCTGLKALLYLKSIEELQDWD GQSPATVSHQKGKPVPRIAELMDKK LPSFGPYLEQRKKIIAENKIRLKEQ NVAFSPLKRNCFIPKRPIPTIKDVI GKALQYLGTFGELSNVEQVVAMIDE EMCINCGKCYMTCNDSGYQAIQFDP ETHLPTITDTCTGCTLCLSVCPIVD CIKMVSRTTPYEPKRGVPLSVNPVC TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | DPYD dihydropyrimidine dehydrogenase [ Homo sapiens (human) ] |
Official Symbol : | DPYD |
Synonyms : | DPYD; dihydropyrimidine dehydrogenase; dihydropyrimidine dehydrogenase [NADP(+)]; DPD; dihydrouracil dehydrogenase; dihydrothymine dehydrogenase; DHP; DHPDHASE; MGC70799; MGC132008; |
Gene ID : | 1806 |
mRNA Refseq : | NM_000110 |
Protein Refseq : | NP_000101 |
MIM : | 612779 |
UniProt ID : | Q12882 |
Products Types
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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