Recombinant Human DPYSL2, GST-tagged
Cat.No. : | DPYSL2-101H |
Product Overview : | Recombinant Human DPYSL2(1 a.a. - 572 a.a.), fused with GST-tag at N-terminal, was expressed in Wheat Germ. |
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Description : | This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 88.7 kDa |
AA Sequence : | MSYQGKKNIPRITSDRLLIKGGKIV NDDQSFYADIYMEDGLIKQIGENLI VPGGVKTIEAHSRMVIPGGIDVHTR FQMPDQGMTSADDFFQGTKAALAGG TTMIIDHVVPEPGTSLLAAFDQWRE WADSKSCCDYSLHVDISEWHKGIQE EMEALVKDHGVNSFLVYMAFKDRFQ LTDCQIYEVLSVIRDIGAIAQVHAE NGDIIAEEQQRILDLGITGPEGHVL SRPEEVEAEAVNRAITIANQTNCPL YITKVMSKSSAEVIAQARKKGTVVY GEPITASLGTDGSHYWSKNWAKAAA FVTSPPLSPDPTTPDFLNSLLSCGD LQVTGSAHCTFNTAQKAVGKDNFTL IPEGTNGTEERMSVIWDKAVVTGKM DENQFVAVTSTNAAKVFNLYPRKGR IAVGSDADLVIWDPDSVKTISAKTH NSSLEYNIFEGMECRGSPLVVISQG KIVLEDGTLHVTEGSGRYIPRKPFP DFVYKRIKARSRLAELRGVPRGLYD GPVCEVSVTPKTVTPASSAKTSPAK QQAPPVRNLHQSGFSLSGAQIDDNI PRRTTQRIVAPPGGRANITSLG |
Applications : | ELISA; WB-Re; AP; Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | DPYSL2?dihydropyrimidinase-like 2 [?Homo sapiens?(human) ] |
Official Symbol : | DPYSL2 |
Synonyms : | DPYSL2; DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2; dihydropyrimidinase-like 2; dihydropyrimidinase-related protein 2; unc-33-like phosphoprotein 2; collapsin response mediator protein hCRMP-2 |
Gene ID : | 1808 |
mRNA Refseq : | NM_001386 |
Protein Refseq : | NP_001377 |
MIM : | 602463 |
UniProt ID : | Q16555 |
Chromosome Location : | 8p22-p21 |
Pathway : | BDNF signaling pathway; CRMPs in Sema3A signaling; Regulation of Microtubule Cytoskeleton |
Function : | dihydropyrimidinase activity; protein binding; protein kinase binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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