Recombinant Human DSG2 protein, His&Myc-tagged

• Cat.No.: DSG2-4426H
• Product Overview: Recombinant Human DSG2 protein(Q14126)(50-609aa), fused to N-terminal His tag and C-terminal Myc tag, was expressed in E. coli

Specification

• Source: E. coli
• Species: Human
• Tag: His&Myc
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 67.5 kDa
• Protein length: 50-609aa
• AA Sequence: AWITAPVALREGEDLSKKNPIAKIH SDLAEERGLKITYKYTGKGITEPPF GIFVFNKDTGELNVTSILDREETPF FLLTGYALDARGNNVEKPLELRIKV LDINDNEPVFTQDVFVGSVEELSAA HTLVMKINATDADEPNTLNSKISYR IVSLEPAYPPVFYLNKDTGEIYTTS VTLDREEHSSYTLTVEARDGNGEVT DKPVKQAQVQIRILDVNDNIPVVEN KVLEGMVEENQVNVEVTRIKVFDAD EIGSDNWLANFTFASGNEGGYFHIE TDAQTNEGIVTLIKEVDYEEMKNLD FSVIVANKAAFHKSIRSKYKPTPIP IKVKVKNVKEGIHFKSSVISIYVSE SMDRSSKGQIIGNFQAFDEDTGLPA HARYVKLEDRDNWISVDSVTSEIKL AKLPDFESRYVQNGTYTVKIVAISE DYPRKTITGTVLINVEDINDNCPTL IEPVQTICHDAEYVNVTAEDLDGHP NSGPFSFSVIDKPPGMAEKWKIARQ ESTSVLLQQSEKKLGRSEIQFLISD NQGFSCPEKQVLTLTVCECLHGSGC REAQHDSYVG
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: DSG2 desmoglein 2 [ Homo sapiens ]
• Official Symbol: DSG2
• Synonyms: DSG2; desmoglein 2; desmoglein-2; CDHF5; HDGC; cadherin family member 5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037
• Gene ID: 1829
• mRNA Refseq: NM_001943
• Protein Refseq: NP_001934
• MIM: 125671
• UniProt ID: Q14126

Reviews

05/05/2021

Unmatched product superiority, professional customer service, and delivery that exceeded expectations.

02/01/2019

A truly delightful buying experience.

07/17/2018

This lab product excels in quality, backed by a customer service team that is not only friendly but also knowledgeable.

Q&As

How does Desmoglein-2 contribute to wound healing and tissue repair, and are there therapeutic implications for manipulating its activity in these processes?

Desmoglein-2 plays a role in wound healing and tissue repair by facilitating cell adhesion and migration. Manipulating its activity may have therapeutic implications for enhancing these processes.

How is the expression of Desmoglein-2 regulated, and what are the consequences of its dysregulation in the context of autoimmune diseases and skin disorders?

Desmoglein-2 expression is regulated at transcriptional and post-translational levels. Dysregulation is linked to autoimmune diseases like pemphigus, where autoantibodies target Desmoglein-2, leading to skin blistering.

Can you elaborate on the molecular structure of Desmoglein-2 and its interactions within desmosomal complexes?

Desmoglein-2 has a unique molecular structure with extracellular domains facilitating cell-cell adhesion. It interacts with other desmosomal components, such as Desmocollins and Plakoglobin, forming strong intercellular junctions.

How does Desmoglein-2 contribute to the regulation of cell signaling pathways, and are there specific pathways influenced by its interactions with other cellular components?

Desmoglein-2 participates in cell signaling, impacting pathways involved in cell adhesion, migration, and survival. Its interactions with other desmosomal components modulate signaling cascades essential for cellular function.

Can you discuss the role of Desmoglein-2 in epithelial-mesenchymal transition (EMT) and its implications for cancer invasion and metastasis?

Desmoglein-2 influences EMT, a process crucial for cancer invasion and metastasis. Changes in Desmoglein-2 expression and localization contribute to alterations in cell adhesion dynamics during EMT.