Recombinant Human DVL1 protein, His & T7-tagged

• Cat.No.: DVL1-1682H
• Product Overview: Recombinant Human DVL1 aa. (Arg150~Lys285 (Accession # O14640)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Description: DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
• Source: E. coli
• Species: Human
• Tag: His & T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 19.0kDa
• Protein length: Arg150~Lys285 (Accession # O14640)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 11.1

Gene Information

• Gene Name: DVL1 dishevelled segment polarity protein 1 [ Homo sapiens (human) ]
• Official Symbol: DVL1
• Synonyms: DVL1; dishevelled segment polarity protein 1; DVL; DRS2; DVL1L1; DVL1P1; segment polarity protein dishevelled homolog DVL-1; DSH homolog 1; dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1; dishevelled-1
• Gene ID: 1855
• mRNA Refseq: NM_001330311.1
• Protein Refseq: NP_001317240.1
• UniProt ID: O14640