Recombinant Human DYNLT1 Protein, His-tagged

• Cat.No.: DYNLT1-2978H
• Product Overview: Human DYNLT1 (NP_006510, 1 a.a. - 113 a.a.) full-length recombinant protein with His tag expressed in Escherichia coli.

Specification

• Description: This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Molecular Mass: 14.6 kDa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMEDYQ AAEETAFVVDEVSNIVKEAIESAIG GNAYQHSKVNQWTTNVVEQTLSQLT KLGKPFKYIVTCVIMQKNGAGLHTA SSCFWDSSTDGSCTVRWENKTMYCI VSAFGLSI
• Purity: > 95% by SDS-PAGE
• Applications: SDS-PAGE
• Storage: Store at 4 centigrade for 1-2 weeks. For long term storage store at -20 centigrade or -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Concentration: 1 mg/mL
• Storage Buffer: In 20 mM Tris-HCl, 0.1M NaCl, pH 8.0 (1 mM dithiothreitol, 30% glycerol)

Gene Information

• Gene Name: DYNLT1 dynein, light chain, Tctex-type 1 [ Homo sapiens ]
• Official Symbol: DYNLT1
• Synonyms: DYNLT1; dynein, light chain, Tctex-type 1; t complex associated testis expressed 1 like 1 , TCTEL1; dynein light chain Tctex-type 1; T-complex testis-specific protein 1 homolog; t-complex-associated-testis-expressed 1-like 1; CW-1; TCTEL1; tctex-1; MGC111571
• Gene ID: 6993
• mRNA Refseq: NM_006519
• Protein Refseq: NP_006510
• MIM: 601554
• UniProt ID: P63172