Recombinant Human ELAC2, GST-tagged
Cat.No. : | ELAC2-12395H |
Product Overview : | Recombinant Human ELAC2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3 trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 86-385a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | ELAC2 elaC homolog 2 (E. coli) [ Homo sapiens ] |
Official Symbol : | ELAC2 |
Synonyms : | ELAC2; elaC homolog 2 (E. coli); elaC (E. coli) homolog 2; zinc phosphodiesterase ELAC protein 2; FLJ10530; HPC2; tRNase Z (long form); RNase Z 2; tRNase Z 2; ribonuclease Z 2; tRNA 3 endonuclease 2; elaC homolog protein 2; heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; ELC2; FLJ36693; FLJ42848; |
Gene ID : | 60528 |
mRNA Refseq : | NM_001165962 |
Protein Refseq : | NP_001159434 |
MIM : | 605367 |
UniProt ID : | Q9BQ52 |
Chromosome Location : | 17p11.2 |
Pathway : | RNA transport, organism-specific biosystem; RNA transport, conserved biosystem; |
Function : | endonuclease activity; hydrolase activity; metal ion binding; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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