Recombinant Human EPHA3 Protein (K579-V983), GST tagged

• Cat.No.: EPHA3-0984H
• Product Overview: Recombinant Human GST-TEV-GG-EPHA3(K579-V983 end) Protein was expressed in Insect cell.

Specification

• Description: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Protein Length: K579-V983
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: EPHA3 EPH receptor A3 [ Homo sapiens (human) ]
• Official Symbol: EPHA3
• Synonyms: EPHA3; EPH receptor A3; EphA3, ETK, ETK1, TYRO4; ephrin type-A receptor 3; HEK; HEK4; EPH-like kinase 4; human embryo kinase 1; eph-like tyrosine kinase 1; TYRO4 protein tyrosine kinase; tyrosine-protein kinase receptor ETK1; EK4; ETK; ETK1; TYRO4
• Gene ID: 2042
• mRNA Refseq: NM_005233
• Protein Refseq: NP_005224
• MIM: 179611
• UniProt ID: P29320