| Description : |
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
107.7 kDa |
| AA Sequence : |
MVFLPLKWSLATMSFLLSSLLALLT VSTPSWCQSTEASPKRSDGTPFPWN KIRLPEYVIPVHYDLLIHANLTTLT FWGTTKVEITASQPTSTIILHSHHL QISRATLRKGAGERLSEEPLQVLEH PRQEQIALLAPEPLLVGLPYTVVIH YAGNLSETFHGFYKSTYRTKEGELR ILASTQFEPTAARMAFPCFDEPAFK ASFSIKIRREPRHLAISNMPLVKSV TVAEGLIEDHFDVTVKMSTYLVAFI ISDFESVSKITKSGVKVSVYAVPDK INQADYALDAAVTLLEFYEDYFSIP YPLPKQDLAAIPDFQSGAMENWGLT TYRESALLFDAEKSSASSKLGITMT VAHELAHQWFGNLVTMEWWNDLWLN EGFAKFMEFVSVSVTHPELKVGDYF FGKCFDAMEVDALNSSHPVSTPVEN PAQIREMFDDVSYDKGACILNMLRE YLSADAFKSGIVQYLQKHSYKNTKN EDLWDSMASICPTDGVKGMDGFCSR SQHSSSSSHWHQEGVDVKTMMNTWT LQKGFPLITITVRGRNVHMKQEHYM KGSDGAPDTGYLWHVPLTFITSKSD MVHRFLLKTKTDVLILPEEVEWIKF NVGMNGYYIVHYEDDGWDSLTGLLK GTHTAVSSNDRASLINNAFQLVSIG KLSIEKALDLSLYLKHETEIMPVFQ GLNELIPMYKLMEKRDMNEVETQFK AFLIRLLRDLIDKQTWTDEGSVSER MLRSQLLLLACVHNYQPCVQRAEGY FRKWKESNGNLSLPVDVTLAVFAVG AQSTEGWDFLYSKYQFSLSSTEKSQ IEFALCRTQNKEKLQWLLDESFKGD KIKTQEFPQILTLIGRNPVGYPLAW QFLRKNWNKLVQKFELGSSSIAHMV MGTTNQFSTRTRLEEVKGFFSSLKE NGSQLRCVQQTIETIEENIGWMDKN FDKIRVWLQSEKLEHDPEADATGTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
