| Description : |
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
71.5 kDa |
| Protein Length : |
1342 |
| AA Sequence : |
MRANDALQVLGLLFSLARGSEVGNS QAVCPGTLNGLSVTGDAENQYQTLY KLYERCEVVMGNLEIVLTGHNADLS FLQWIREVTGYVLVAMNEFSTLPLP NLRVVRGTQVYDGKFAIFVMLNYNT NSSHALRQLRLTQLTEILSGGVYIE KNDKLCHMDTIDWRDIVRDRDAEIV VKDNGRSCPPCHEVCKGRCWGPGSE DCQTLTKTICAPQCNGHCFGPNPNQ CCHDECAGGCSGPQDTDCFACRHFN DSGACVPRCPQPLVYNKLTFQLEPN PHTKYQYGGVCVASCPHNFVVDQTS CVRACPPDKMEVDKNGLKMCEPCGG LCPKACEGTGSGSRFQTVDSSNIDG FVNCTKILGNLDFLITGLNGDPWHK IPALDPEKLNVFRTVREITGYLNIQ SWPPHMHNFSVFSNLTTIGGRSLYN RGFSLLIMKNLNVTSLGFRSLKEIS AGRIYISANRQLCYHHSLNWTKVLR GPTEERLDIKHNRPRRDCVAEGKVC DPLCSSGGCWGPGPGQCLSCRNYSR GGVCVTHCNFLNGEPREFAHEAECF SCHPECQPMEGTATCNGSGSDTCAQ CAHFRDGPHCVSSCPHGVLGAKGPI YKYPDVQNECRPCHENCTQGCKGPE LQDCLGQTLVLIGKTHLTMALTVIA GLVVIFMMLGGTFLYWRGRRIQNKR AMRRYLERGESIEPLDPSEKANKVL ARIFKETELRKLKVLGSGVFGTVHK GVWIPEGESIKIPVCIKVIEDKSGR QSFQAVTDHMLAIGSLDHAHIVRLL GLCPGSSLQLVTQYLPLGSLLDHVR QHRGALGPQLLLNWGVQIAKGMYYL EEHGMVHRNLAARNVLLKSPSQVQV ADFGVADLLPPDDKQLLYSEAKTPI KWMALESIHFGKYTHQSDVWSYGVT VWELMTFGAEPYAGLRLAEVPDLLE KGERLAQPQICTIDVYMVMVKCWMI DENIRPTFKELANEFTRMARDPPRY LVIKRESGPGIAPGPEPHGLTNKKL EEVELEPELDLDLDLEAEEDNLATT TLGSALSLPVGTLNRPRGSQSLLSP SSGYMPMNQGNLGESCQESAVSGSS ERCPRPVSLHPMPRGCLASESSEGH VTGSEAELQEKVSMCRSRSRSRSPR PRGDSAYHSQRHSLLTPVTPLSPPG LEEEDVNGYVMPDTHLKGTPSSREG TLSSVGLSSVLGTEEEDEDEEYEYM NRRRRHSPPHPPRPSSLEELGYEYM DVGSDLSASLGSTQSCPLHPVPIMP TAGTTPDEDYEYMNRQRDGGGPGGD YAAMGACPASEQGYEEMRAFQGPGH QAPHVHYARLKTLRSLEATDSAFDN PDYWHSRLFPKANAQRT |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
