Recombinant Human ERCC8 Protein, His&GST-tagged

• Cat.No.: ERCC8-1436H
• Product Overview: Recombinant Human ERCC8 Protein (Met1-Gly396) with N-His&GST tag was expressed in E. coli.

Specification

• Description: This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: N-His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 74.1 kDa
  Accurate Molecular Mass: 74 kDa
• Protein length: Met1-Gly396
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: ERCC8 excision repair cross-complementing rodent repair deficiency, complementation group 8 [ Homo sapiens (human) ]
• Official Symbol: ERCC8
• Synonyms: ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8; CKN1, Cockayne syndrome 1 (classical); DNA excision repair protein ERCC-8; CSA; Cockayne syndrome WD-repeat protein CSA; cockayne syndrome WD repeat protein CSA; CKN1
• Gene ID: 1161
• mRNA Refseq: NM_000082
• Protein Refseq: NP_000073
• MIM: 609412
• UniProt ID: Q13216