Recombinant Human ESR1 Protein, Full Length, N-FLAG tagged

• Cat.No.: ESR1-13HFL
• Product Overview: Recombinant Estrogen Receptor-alpha protein was expressed in baculovirus system as the full length protein (accession number NP_000116.2) with an N-terminal FLAG tag.

Specification

• Description: This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain.
• Source: Insect cells
• Species: Human
• Tag: N-FLAG
• Protein length: Full Length
• Molecular Mass: 67.5 kDa
• Purity: > 80%
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
• Storage Buffer: Recombinant Estrogen Receptor-alpha protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5 mM TCEP.

Gene Information

• Gene Name: ESR1 estrogen receptor 1 [ Homo sapiens (human) ]
• Official Symbol: ESR1
• Synonyms: ESR1; estrogen receptor 1; ER; ESR; Era; ESRA; ESTRR; NR3A1; estrogen receptor; E2 receptor alpha; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1; oestrogen receptor alpha
• Gene ID: 2099
• mRNA Refseq: NM_000125
• Protein Refseq: NP_000116
• MIM: 133430
• UniProt ID: P03372

Reviews

05/30/2021

Its high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.

04/24/2019

Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.

12/08/2017

With the ESR1 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.

Q&As

What are the clinical implications of ESR1 mutations in breast cancer?

ESR1 mutations can lead to resistance to endocrine therapies in breast cancer patients, impacting treatment outcomes.

How does ESR1 testing impact the prognosis of breast cancer patients?

ESR1 testing can provide important prognostic information by helping to predict the likelihood of a favorable response to hormone therapy.

How is ESR1 protein detected in clinical practice?

ESR1 protein can be detected through various laboratory techniques, including immunohistochemistry (IHC) and immunoblotting.

Can ESR1 mutations be targeted in breast cancer treatment?

Research is ongoing, and there are efforts to develop targeted therapies for ESR1-mutated breast cancer, but it's still an evolving field.

How is ESR1 status determined in breast cancer patients?

ESR1 status is determined through the examination of tumor tissue samples, often using IHC or molecular testing.