Recombinant Human ESR1 Protein (Met297-Ser554), His tagged
Cat.No. : | ESR1-2301H |
Product Overview : | Recombinant human Era (Met297-Ser554) protein fused with His tag was expressed in E. coli. |
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Description : | An ESR1 gene mutation, which encodes for the estrogen receptor (ER) protein, is one of the potential mechanisms of therapy resistance. The ESR1 mutations result in conformational changes in the ER leading to subsequent estrogen-independent transcriptional activity. The mutations within the estrogen receptor (ER) gene, ESR1, frequently occur in metastatic breast cancer and influence response to hormone therapy. Estrogen receptor alpha (ERalpha) is one of the estrogen hormone-activated transcription factors, which regulates a large number of genes and is involved in the mammary gland development. Expression of ERalpha is considered to be a good indicator for endocrine therapy and breast cancer survival. Loss of ERalpha in breast cancer patients indicates invasiveness and poor prognosis. ESR1 as a direct target of miR-31a-3p and suggest that miR-31a-3p likely contributes to development of estrogen independence, which leads to a more invasive phenotype of breast cancer. Polymorphisms of the estrogen receptor gene alpha (ESR1) are consistently been associated with bone mineral density (BMD) and fracture. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | 30.07 kDa |
Protein Length : | Met297-Ser554 |
Purity : | >90 % as determined by SDS-PAGE. |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | ESR1 estrogen receptor 1 [ Homo sapiens (human) ] |
Official Symbol : | ESR1 |
Synonyms : | ESR1; estrogen receptor 1; ESR; estrogen receptor; Era; NR3A1; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen receptor alpha 3*,4,5,6,7*/822 isoform; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform; ER; ESRA; DKFZp686N23123; |
Gene ID : | 2099 |
mRNA Refseq : | NM_000125 |
Protein Refseq : | NP_000116 |
MIM : | 133430 |
UniProt ID : | P03372 |
Products Types
◆ Recombinant Protein | ||
ESR1-014H | Recombinant Human ESR1 Protein | +Inquiry |
ESR1-118H | Recombinant Human ESR1 protein, His-tagged | +Inquiry |
ESR1-02H | Recombinant Human ESR1 Protein, His-tagged | +Inquiry |
ESR1-868H | Recombinant Human ESR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Esr1-977M | Recombinant Mouse Esr1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
ESR1-6540HCL | Recombinant Human ESR1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionESR1 mutations can lead to resistance to endocrine therapies in breast cancer patients, impacting treatment outcomes.
ESR1 testing can provide important prognostic information by helping to predict the likelihood of a favorable response to hormone therapy.
ESR1 protein can be detected through various laboratory techniques, including immunohistochemistry (IHC) and immunoblotting.
Research is ongoing, and there are efforts to develop targeted therapies for ESR1-mutated breast cancer, but it's still an evolving field.
ESR1 status is determined through the examination of tumor tissue samples, often using IHC or molecular testing.
Customer Reviews (3)
Write a reviewIts high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.
Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.
With the ESR1 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.
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