Recombinant Human Estrogen Receptor 1

• Cat.No.: ESR1-2639H
• Product Overview: Recombinant human estrogen receptor-β expressed inS. frugiperda insect cells. A hormone-inducible transcription factor that shares high homology with ER-α, especially in the DNA binding protein domain, suggesting that both receptors interact with related DNA response elements.

Specification

• Cat. No.: ESR1-2639H
• Description: In the field of molecular biology, nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism.
• Source: S. frugiperda insect cells.
• Form: Liquid.
• Formulation: In 400 mM KCl, 50 mM Bis-Tris-propane, 2 mM DTT, 1 mM EDTA, 10% glycerol, pH 9.0. DO NOT VORTEX.
• Molar Mass: 53000 Da.
• Specific Activity: ≥5000 units/mg protein.
• Unit Definition: One unit is defined as the amount of estrogen receptor that will bind 1.0 pmol 3H-estradiol overnight at 4°C as measured by quantitation of estradiol:receptor complexes in a hydroxylapatite assay.
• Purity: ≥80% by SDS-PAGE.
• Storage: ≤ -70oC. Ship: Dry Ice Only.

Gene Information

• Gene Name: ESR1 estrogen receptor 1 [ Homo sapiens ]
• Synonyms:
  ESR1; estrogen receptor 1; ER-alpha; estradiol receptor; estrogen receptor; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor alpha delta 4 +49 isoform; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; nuclear receptor subfamily 3 group A member 1; ER; ESR; Era; ESRA; NR3A1; DKFZp686N23123
• Gene ID: 2099
• mRNA Refseq: NM_000125
• Protein Refseq: NP_000116
• MIM: 133430
• UniProt ID: P03372
• Chromosome Location: 6q25.1
• Pathway: Gene Expression
• Function: estrogen response element binding; hormone binding; metal ion binding; nitric-oxide synthase regulator activity; protein binding; protein complex binding; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; transcription factor activity; transcription factor binding; zinc ion binding

Reviews

05/30/2021

Its high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.

04/24/2019

Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.

12/08/2017

With the ESR1 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.

Q&As

What are the clinical implications of ESR1 mutations in breast cancer?

ESR1 mutations can lead to resistance to endocrine therapies in breast cancer patients, impacting treatment outcomes.

How does ESR1 testing impact the prognosis of breast cancer patients?

ESR1 testing can provide important prognostic information by helping to predict the likelihood of a favorable response to hormone therapy.

How is ESR1 protein detected in clinical practice?

ESR1 protein can be detected through various laboratory techniques, including immunohistochemistry (IHC) and immunoblotting.

Can ESR1 mutations be targeted in breast cancer treatment?

Research is ongoing, and there are efforts to develop targeted therapies for ESR1-mutated breast cancer, but it's still an evolving field.

How is ESR1 status determined in breast cancer patients?

ESR1 status is determined through the examination of tumor tissue samples, often using IHC or molecular testing.