Recombinant Human Estrogen Receptor 1, His-tagged
Cat.No. : | ESR1-01H |
Product Overview : | Recombinant Human Estrogen Receptor 1(NP_000116.2), fused to His-tag, was expressed in E. coli. |
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Description : | This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 20 mM Tris-HCl, 150 mM NaCl, pH 8.0 |
Molecular Mass : | The protein has a calculated MW of 27.3 kDa. |
AA Sequence : | MTMTLHTKASGMALLHQIQGNELEP LNRPQLKIPLERPLGEVYLDSSKPA VYNYPEGAAYEFNAAAAANAQVYGQ TGLPYGPGSEAAAFGSNGLGGFPPL NSVSPSPLMLLHPPPQLSPFLQPHG QQVPYYLENEPSGYTVREAGPPAFY RPNSDNRRQGGRERLASTNDKGSMA MESAKETRYCAVCNDYASGYHYGVW SCEGCKAFFKRSIQGHNDYMCPATN QCTIDKNRRKSCQACRLRKCYEVG |
Storage : | Store it under sterile conditions at -20 to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 0.13 mg/ml |
Gene Name : | ESR1 estrogen receptor 1 [ Homo sapiens (human) ] |
Official Symbol : | ESR1 |
Synonyms : | ER; ESR; Era; ESRA; ESTRR; NR3A1 |
Gene ID : | 2099 |
mRNA Refseq : | NM_000125.4 |
Protein Refseq : | NP_000116.2 |
MIM : | 133430 |
UniProt ID : | P03372 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionESR1 mutations can lead to resistance to endocrine therapies in breast cancer patients, impacting treatment outcomes.
ESR1 testing can provide important prognostic information by helping to predict the likelihood of a favorable response to hormone therapy.
ESR1 protein can be detected through various laboratory techniques, including immunohistochemistry (IHC) and immunoblotting.
Research is ongoing, and there are efforts to develop targeted therapies for ESR1-mutated breast cancer, but it's still an evolving field.
ESR1 status is determined through the examination of tumor tissue samples, often using IHC or molecular testing.
Customer Reviews (3)
Write a reviewIts high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.
Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.
With the ESR1 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.
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