| Description : |
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Supplied as a 0.2 μm filtered solution of 50 mM NaCl,5% Sucrose, 1% Tween 20 (v/v),0.3% Histidine (w/v),pH8.0. |
| Protein length : |
Gly39-Met732 |
| AA Sequence : |
GVNLQEFLNVTSVHLFKERWDTNKV DHHTDKYENNKLIVRRGQSFYVQID FSRPYDPRRDLFRVE YVIGRYPQENKGTYIPVPIVSELQS GKWGAKIVMREDRSVRLSIQSSPKC IVGKFRMYVAVWTPY GVLRTSRNPETDTYILFNPWCEDDA VYLDNEKEREEYVLNDIGVIFYGEV NDIKTRSWSYGQFED GILDTCLYVMDRAQMDLSGRGNPIK VSRVGSAMVNAKDDEGVLVGSWDNI YAYGVPPSAWTGSVD ILLEYRSSENPVRYGQCWVFAGVFN TFLRCLGIPARIVTNYFSAHDNDAN LQMDIFLEEDGNVNS KLTKDSVWNYHCWNEAWMTRPDLPV GFGGWQAVDSTPQENSDGMYRCGPA SVQAIKHGHVCFQFD APFVFAEVNSDLIYITAKKDGTHVV ENVDATHIGKLIVTKQIGGDGMMDI TDTYKFQEGQEEERL ALETALMYGAKKPLNTEGVMKSRSN VDMDFEVENAVLGKDFKLSITFRNN SHNRYTITAYLSANI TFYTGVPKAEFKKETFDVTLEPLSF KKEAVLIQAGEYMGQLLEQASLHFF VTARINETRDVLAKQ KSTVLTIPEIIIKVRGTQVVGSDMT VTVQFTNPLKETLRNVWVHLDGPGV TRPMKKMFREIRPNS TVQWEEVCRPWVSGHRKLIASMSSD SLRHVYGELDVQIQRRPSMVDHHHH HH |
| Endotoxin : |
Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test. |
| Purity : |
Greater than 95% as determined by reducing SDS-PAGE. |
| Storage : |
Store at < -20 centigrade, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. |
| Shipping : |
The product is shipped on dry ice/ice packs. |
