Recombinant Human FABP1, His-tagged

• Cat.No.: FABP1-3685H
• Product Overview: Total 137 AA. MW: 15.45 kDa (calculated). N-Terminal His-tag, 10 extra AA (highlighted).

Specification

• Cat. No.: FABP1-3685H
• Description: FABP1 encodes the fatty acid-binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.
• Source: E. coli
• Species: Human
• Form: Filtered (0, 4 μm) and lyophilized in 0.5 mg/mL in 20mM TRIS, 50 mM NaCl, Ph 7.5
• Research topic: Energy metabolism and body weight regulation
• Reconstitution: Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
• Applications: ELISA; Western blotting
• Quality Control Test: BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein
• Sequences of amino acids: MKHHHHHHAS MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF KRISKRI
• Storage: Store lyophilized protein at -80°C. Lyophilized protein remains stable until the expiry date when stored at -80°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for one week.

Gene Information

• Gene Name: FABP1 fatty acid binding protein 1, liver [ Homo sapiens ]
• Official Symbol: FABP1
• Synonyms: FABP1; fatty acid binding protein 1, liver; FABPL; L-FABP; fatty acid-binding protein, liver; OTTHUMP00000160828; OTTHUMP00000160829; fatty acid-binding protein 1; liver-type fatty acid-binding protein
• Gene ID: 2168
• mRNA Refseq: NM_001443
• Protein Refseq: NP_001434
• MIM: 134650
• UniProt ID: P07148
• Chromosome Location: 2p11
• Pathway: Fat digestion and absorption; PPAR signaling pathway; Selenium Metabolism and Selenoproteins
• Function: bile acid binding; chromatin binding; drug binding; fatty acid binding; long-chain fatty acid transporter activity; phospholipid binding; transporter activity

Reviews

07/24/2019

One notable advantage of using the FABP1 protein is the outstanding technical support provided by its manufacturer.

05/28/2019

Its purity and functionality have been extensively tested, ensuring reliable and reproducible results in my research.

05/22/2019

The knowledgeable and responsive support team offers valuable assistance and expertise, making troubleshooting and problem-solving much more efficient.

Q&As

How is FABP1 linked to metabolic disorders?

Elevated levels of FABP1 are associated with metabolic disorders like obesity and insulin resistance, making it a potential indicator for these conditions.

How is FABP1 involved in fatty acid metabolism?

FABP1 binds to fatty acids, facilitating their transport and metabolism within liver cells.

Are there other organs where FABP1 is expressed?

While predominantly found in the liver, FABP1 is also expressed in the small intestine and kidney.

Can FABP1 be used for early detection of liver damage?

Yes, elevated FABP1 levels in blood or urine may indicate early stages of liver damage, enabling early intervention.

Are there genetic variations influencing FABP1 expression?

Genetic variations may contribute to differences in FABP1 expression, impacting an individual's susceptibility to certain diseases.