Recombinant Human Fas (TNFRSF6)-associated via death domain, His-tagged
Cat.No. : | FADD-4351H |
Product Overview : | FADD produced in E.Coli is a single, non-glycosylated polypeptide chain containing 244 amino acids (1-208 a.a.) and having a molecular mass of 27.4 kDa. FADD is fused to 36 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | FADD-4351H |
Description : | FADD is an adaptor protein that cooperates with a variety of cell surface receptors and mediates cell apoptotic signals. Using its C-terminal death domain, FADD is recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and consequently it take parts in the death signaling initiated by these receptors. FADD interaction with the receptors reviels the N-terminal effector domain of, which allows it to recruit caspase-8, and thus initiate the cysteine protease cascade. Knockout studies in mice furthermore propose the significance of FADD in premature T cell development. FADD plays a role in survival/proliferation and cell cycle development. FADD also takes part in cellular sublocalization, protein phosphorylation, and inhibitory molecules. |
Source : | Human |
Host : | Escherichia Coli |
Form : | The FADD protein solution contains 20mM Tris-HCl, pH-8, and 10% glycerol. |
Purity : | Greater than 95.0% as determined by SDS-PAGE. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Amino acid sequence : | MRGSHHHHHHGMASMTGGQQM GRDLYDDDDKDRWGSMDPFLVLL HSVSSSLSSSELTELKFLCLGRVGK RKLERVQSGLDLFSMLLEQND LEPGHTELLRELLASLRRHDLLRRV DDFEAGAAAGAAPGEEDLCAAFNVI CDNVGKDWRRLARQLKVSDTKIDSI EDRYPRNLTERVRESLRIWKN TEKENATVAHLVGALRSCQMNLVAD LVQEVQQARDLQNRSGAMSPMSWN SDAST SEAS |
Storage : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
Pathways : | Apoptosis; Toll-like receptor signaling pathway; Apoptosis |
Functions : | death receptor binding; identical protein binding |
Gene Name : | FADD Fas (TNFRSF6)-associated via death domain [ Homo sapiens ] |
Official Symbol : | FADD |
Synonyms : | FADD; Fas (TNFRSF6)-associated via death domain; GIG3; MORT1; MGC8528; Fas-associated via death domain; growth-inhibiting gene 3 protein; mediator of receptor-induced toxicity; Fas-associating protein with death domain; Fas-associating death domain-containing protein; mediator of receptor-induced toxicity; Protein FADD; Mediator of receptor induced toxicity |
Gene ID : | 8772 |
mRNA Refseq : | NM_003824 |
Protein Refseq : | NP_003815 |
MIM : | 602457 |
UniProt ID : | Q13158 |
Chromosome Location : | 11q13.3 |
Products Types
◆ Recombinant Protein | ||
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FADD-2352E | Recombinant Escherichia coli FADD Protein (1-561 aa), His-tagged | +Inquiry |
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◆ Lysates | ||
FADD-6473HCL | Recombinant Human FADD 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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