Recombinant Human FBP1 Protein (Met1-Gln338), His tagged

• Cat.No.: FBP1-2428H
• Product Overview: Recombinant human FBP1 (Met1-Gln338) protein fused with His tag was expressed in E. coli.

Specification

• Description: Catalyzes the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 36.92 kDa
• Protein Length: Met1-Gln338
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: FBP1 fructose-1,6-bisphosphatase 1 [ Homo sapiens (human) ]
• Official Symbol: FBP1
• Synonyms: FBP1; fructose-1,6-bisphosphatase 1; FBP; FBPase 1; fructose-bisphosphatase 1; growth-inhibiting protein 17; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
• Gene ID: 2203
• mRNA Refseq: NM_000507
• Protein Refseq: NP_000498
• MIM: 611570
• UniProt ID: P09467