| Description : |
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
75.4 kDa |
| AA Sequence : |
MAGMKTASGDYIDSSWELRVFVGEE DPEAESVTLRVTGESHIGGVLLKIV EQINRKQDWSDHAIWWEQKRQWLLQ THWTLDKYGILADARLFFGPQHRPV ILRLPNRRALRLRASFSQPLFQAVA AICRLLSIRHPEELSLLRAPEKKEK KKKEKEPEEELYDLSKVVLAGGVAP ALFRGMPAHFSDSAQTEACYHMLSR PQPPPDPLLLQRLPRPSSLSDKTQL HSRWLDSSRCLMQQGIKAGDALWLR FKYYSFFDLDPKTDPVRLTQLYEQA RWDLLLEEIDCTEEEMMVFAALQYH INKLSQSGEVGEPAGTDPGLDDLDV ALSNLEVKLEGSAPTDVLDSLTTIP ELKDHLRIFRPRKLTLKGYRQHWVV FKETTLSYYKSQDEAPGDPIQQLNL KGCEVVPDVNVSGQKFCIKLLVPSP EGMSEIYLRCQDEQQYARWMAGCRL ASKGRTMADSSYTSEVQAILAFLSL QRTGSGGPGNHPHGPDASAEGLNPY GLVAPRFQRKFKAKQLTPRILEAHQ NVAQLSLAEAQLRFIQAWQSLPDFG ISYVMVRFKGSRKDEILGIANNRLI RIDLAVGDVVKTWRFSNMRQWNVNW DIRQVAIEFDEHINVAFSCVSASCR IVHEYIGGYIFLSTRERARGEELDE DLFLQLTGGHEAFTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
