| Description : |
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
103.6 kDa |
| AA Sequence : |
MPTAAAPIISSVQKLVLYETRARYF LVGSNNAETKYRVLKIDRTEPKDLV IIDDRHVYTQQEVRELLGRLDLGNR TKMGQKGSSGLFRAVSAFGVVGFVR FLEGYYIVLITKRRKMADIGGHAIY KVEDTNMIYIPNDSVRVTHPDEARY LRIFQNVDLSSNFYFSYSYDLSHSL QYNLTVLRMPLEMLKSEMTQNRQES FDIFEDEGLITQGGSGVFGICSEPY MKYVWNGELLDIIKSTVHRDWLLYI IHGFCGQSKLLIYGRPVYVTLIARR SSKFAGTRFLKRGANCEGDVANEVE TEQILCDASVMSFTAGSYSSYVQVR GSVPLYWSQDISTMMPKPPITLDQA DPFAHVAALHFDQMFQRFGSPIIIL NLVKEREKRKHERILSEELVAAVTY LNQFLPPEHTIVYIPWDMAKYTKSK LCNVLDRLNVIAESVVKKTGFFVNR PDSYCSILRPDEKWNELGGCVIPTG RLQTGILRTNCVDCLDRTNTAQFMV GKCALAYQLYSLGLIDKPNLQFDTD AVRLFEELYEDHGDTLSLQYGGSQL VHRVKTYRKIAPWTQHSKDIMQTLS RYYSNAFSDADRQDSINLFLGVFHP TEGKPHLWELPTDFYLHHKNTMRLL PTRRSYTYWWTPEVIKHLPLPYDEV ICAVNLKKLIVKKFHKYEEEIDIHN EFFRPYELSSFDDTFCLAMTSSARD FMPKTVGIDPSPFTVRKPDETGKSV LGNKSNREEAVLQRKTAASAPPPPS EEAVSSSSEDDSGTDREEEGSVSQR STPVKMTDAGDSAKVTENVVQPMKE LYGINLSDGLSEEDFSIYSRFVQLG QSQHKQDKNSQQPCSRCSDGVIKLT PISAFSQDNIYEVQPPRVDRKSTEI FQAHIQASQGIMQPLGKEDSSMYRE YIRNRYLTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
