Recombinant Human FKBP1A
Cat.No. : | FKBP1A-28908TH |
Product Overview : | Recombinant full length Human FKBP12 |
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Description : | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. |
Source : | E. coli |
Form : | Liquid |
Storage buffer : | Preservative: 1mM Sodium AzideConstituents: 50mM Sodium chloride, 10mM HEPES, 0.5mM DTT, pH 8Note: This product can be dissolved further into aqueous buffers for use, but these solutions should not be frozen. |
Storage : | Store at +4°C. Do not freeze. |
Sequence Similarities : | Belongs to the FKBP-type PPIase family. FKBP1 subfamily.Contains 1 PPIase FKBP-type domain. |
Gene Name : | FKBP1A FK506 binding protein 1A, 12kDa [ Homo sapiens ] |
Official Symbol : | FKBP1A |
Synonyms : | FKBP1A; FK506 binding protein 1A, 12kDa; FK506 binding protein 1A (12kD) , FKBP1; peptidyl-prolyl cis-trans isomerase FKBP1A; FKBP 12; FKBP12; FKBP12C; PKC12; PPIASE; |
Gene ID : | 2280 |
mRNA Refseq : | NM_000801 |
Protein Refseq : | NP_000792 |
MIM : | 186945 |
Uniprot ID : | P62942 |
Chromosome Location : | 20p13 |
Pathway : | ALK1 pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; Alpha-synuclein signaling, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; |
Function : | FK506 binding; FK506 binding; SMAD binding; activin binding; isomerase activity; |
Products Types
◆ Recombinant Protein | ||
FKBP1A-916H | Recombinant Human FKBP1A Protein, His (Fc)-Avi-tagged | +Inquiry |
FKBP1A-1540R | Recombinant Rhesus Macaque FKBP1A Protein, His (Fc)-Avi-tagged | +Inquiry |
FKBP1A-2009R | Recombinant Rat FKBP1A Protein, His (Fc)-Avi-tagged | +Inquiry |
Fkbp1a-3098M | Recombinant Mouse Fkbp1a protein(Gly2-Glu108), His-tagged | +Inquiry |
FKBP1A-057H | Recombinant Human FKBP1A Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Lysates | ||
FKBP1A-6210HCL | Recombinant Human FKBP1A 293 Cell Lysate | +Inquiry |
FKBP1A-6211HCL | Recombinant Human FKBP1A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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