Recombinant Human FLT1 Protein, His-tagged

• Cat.No.: FLT1-24H
• Product Overview: Recombinant Human FLT1 Protein, fused to His-tag, was expressed in HEK293.

Specification

• Description: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized from PBS pH7.4, 5% Trehalose, 5% mannitol.
• Molecular Mass: 35.56 kDa
• AA Sequence: SKLKDPELSLKGTQHIMQAGQTLHL QCRGEAAHKWSLPEMVSKESERLSI TKSACGRNGKQFCSTLTLNTAQANH TGFYSCKYLAVPTSKKKETESAIYI FISDTGRPFVEMYSEIPEIIHMTEG RELVIPCRVTSPNITVTLKKFPLDT LIPDGKRIIWDSRKGFIISNATYKE IGLLTCEATVNGHLYKTNYLTHRQT NTIIDVQISTPRPVKLLRGHTLVLN CTATTPLNTRVQMTWSYPDEKNKRA SVRRRIDQSNSHANIFYSVLTIDKM QNKDKGLYTCRVR SGPSFKSVNTSVHIAHHHHHHHHHH
• Endotoxin: ＜1EU/ug by LAL.
• Purity: ＞97%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: FLT1 fms related receptor tyrosine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: FLT1
• Synonyms: FLT; FLT-1; VEGFR1; VEGFR-1
• Gene ID: 2321
• mRNA Refseq: NM_002019.
• Protein Refseq: NP_002010
• MIM: 165070
• UniProt ID: P17948