| Description : |
FMS-related tyrosine kinase 3 (FLT3, also called Flk2), is a member of the type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system. FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream targets. The p85 subunit of PI3 kinase, SHP2, GRB2 and Shc are associated with FLT3 after FL stimulation. Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regulation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of internal tandem duplications (ITDs) occur in 20% of patients with acute myeloid leukemia. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
C-His |
| Molecular Mass : |
~57 kDa |
| AA Sequence : |
NQDLPVIKCVLINHKNNDSSVGKSS SYPMVSESPEDLGCALRPQSSGTVY EAAAVEVDVSASITLQVLVDAPGNI SCLWVFKHSSLNCQPHFDLQNRGVV SMVILKMTETQAGEYLLFIQSEATN YTILFTVSIRNTLLYTLRRPYFRKM ENQDALVCISESVPEPIVEWVLCDS QGESCKEESPAVVKKEEKVLHELFG TDIRCCARNELGRECTRLFTIDLNQ TPQTTLPQLFLKVGEPLWIRCKAVH VNHGFGLTWELENKALEEGNYFEMS TYSTNRTMIRILFAFVSSVARNDTG YYTCSSSKHPSQSALVTIVEKGFIN ATNSSEDYEIDQYEEFCFSVRFKAY PQIRCTWTFSRKSFPCEQKGLDNGY SISKFCNHKHQPGEYIFHAENDDAQ FTKMFTLNIRRKPQVLAEASASQAS CFSDGYPLPSWTWKKCSDKSPNCTE EITEGVWNRKANRKVFGQWVSSSTL NMSEAIKGFLVKCCAYNSLGTSCET ILLNSPGPFPFIQDNIS |
| Purity : |
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Notes : |
For research use only, not for use in diagnostic procedure. |
| Storage : |
Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
| Concentration : |
≥0.5 mg/mL |
| Storage Buffer : |
PBS, 4M Urea, pH7.4 |
