| Description : |
Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
63.3 kDa |
| AA Sequence : |
MAKKVAVIGAGVSGLSSIKCCVDED LEPTCFERSDDIGGLWKFTESSKDG MTRVYKSLVTNVCKEMSCYSDFPFH EDYPNFMNHEKFWDYLQEFAEHFDL LKYIQFKTTVCSITKRPDFSETGQW DVVTETEGKQNRAVFDAVMVCTGHF LNPHLPLEAFPGIHKFKGQILHSQE YKIPEGFQGKRVLVIGLGNTGGDIA VELSRTAAQVLLSTRTGTWVLGRSS DWGYPYNMMVTRRCCSFIAQVLPSR FLNWIQERKLNKRFNHEDYGLSITK GKKAKFIVNDELPNCILCGAITMKT SVIEFTETSAVFEDGTVEENIDVVI FTTGYTFSFPFFEEPLKSLCTKKIF LYKQVFPLNLERATLAIIGLIGLKG SILSGTELQARWVTRVFKGLCKIPP SQKLMMEATEKEQLIKRGVFKDTSK DKFDYIAYMDDIAACIGTKPSIPLL FLKDPRLAWEVFFGPCTPYQYRLMG PGKWDGARNAILTQWDRTLKPLKTR IVPDSSKPASMSHYLKAWGAPVLLA SLLLICKSSLFLKLVRDKLQDRMSP YLVSLWRGSGPTRTRPLEQKLISEE DLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
