Recombinant Human FOXP2 Protein, His&GST-tagged

• Cat.No.: FOXP2-1523H
• Product Overview: Recombinant Human FOXP2 Protein (Met1-Ile244) with N-His&GST tag was expressed in E. coli.

Specification

• Description: This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
• Source: E. coli
• Species: Human
• Tag: N-His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 58.3 kDa
  Accurate Molecular Mass: 58 kDa
• Protein length: Met1-Ile244
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: FOXP2 forkhead box P2 [ Homo sapiens (human) ]
• Official Symbol: FOXP2
• Synonyms: FOXP2; forkhead box P2; SPCH1, TNRC10; forkhead box protein P2; CAG repeat protein 44; CAGH44; forkhead/winged helix transcription factor; speech and language disorder 1; trinucleotide repeat containing 10; forkhead/winged-helix transcription factor; trinucleotide repeat-containing gene 10 protein; SPCH1; TNRC10; DKFZp686H1726
• Gene ID: 93986
• mRNA Refseq: NM_001172766
• Protein Refseq: NP_001166237
• MIM: 605317
• UniProt ID: O15409