| Description : |
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
79.9 kDa |
| AA Sequence : |
MMQESATETISNSSMNQNGMSTLSS QLDAGSRDGRSSGDTSSEVSTVELL HLQQQQALQAARQLLLQQQTSGLKS PKSSDKQRPLQVPVSVAMMTPQVIT PQQMQQILQQQVLSPQQLQALLQQQ QAVMLQQQQLQEFYKKQQEQLHLQL LQQQQQQQQQQQQQQQQQQQQQQQQ QQQQQQQQQQQQQQQQHPGKQAKEQ QQQQQQQQQLAAQQLVFQQQLLQMQ QLQQQQHLLSLQRQGLISIPPGQAA LPVQSLPQAGLSPAEIQQLWKEVTG VHSMEDNGIKHGGLDLTTNNSSSTT SSNTSKASPPITHHSIVNGQSSVLS ARRDSSSHEETGASHTLYGHGVCKW PGCESICEDFGQFLKHLNNEHALDD RSTAQCRVQMQVVQQLEIQLSKERE RLQAMMTHLHMRPSEPKPSPKPLNL VSSVTMSKNMLETSPQSLPQTPTTP TAPVTPITQGPSVITPASVPNVGAI RRRHSDKYNIPMSSEIAPNYEFYKN ADVRPPFTYATLIRQAIMESSDRQL TLNEIYSWFTRTFAYFRRNAATWKN AVRHNLSLHKCFVRVENVKGAVWTV DEVEYQKRRSQKITGSPTLVKNIPT SLGYGAALNASLQAALAESSLPLLS NPGLINNASSGLLQAVHEDLNGSLD HIDSNGNSSPGCSPQPHIHSIHVKE EPVIAEDEDCPMSLVTTANHSPELE DDREIEEEPLSEDLETRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
