Recombinant Human FOXP3 protein, GST-tagged

• Cat.No.: FOXP3-60H
• Product Overview: Recombinant Human FOXP3 protein(107-196 aa), fused to N-terminal GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 100mM GSH.
• Protein length: 107-196 aa
• AA Sequence: STVDAHARTPVLQVHPLESPAMISL TPPTTATGVFSLKARPGLPPGINVA SLEWVSREPALLCTFPNPSAPRKDS TLSAVPQSSYPLLAN
• Purity: 90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: FOXP3 forkhead box P3 [ Homo sapiens ]
• Official Symbol: FOXP3
• Synonyms: FOXP3; forkhead box P3; immune dysregulation, polyendocrinopathy, enteropathy, X linked , IPEX; forkhead box protein P3; AIID; DIETER; JM2; PIDX; SCURFIN; XPID; scurfin; FOXP3delta7; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; IPEX; MGC141961; MGC141963
• Gene ID: 50943
• mRNA Refseq: NM_001114377
• Protein Refseq: NP_001107849
• MIM: 300292
• UniProt ID: Q9BZS1

Reviews

09/14/2022

Its purity and integrity are of the highest standard, ensuring reliable and reproducible results in my research.

03/09/2016

The FOXP3 protein offered by the manufacturer is of exceptional quality and is expected to perfectly meet my experimental needs.

02/03/2016

The manufacturer's commitment to providing excellent technical support is commendable, as their dedicated team possesses the expertise to solve any issue or query that may arise during my experiments.

Q&As

Can FOXP3 be a biomarker for certain diseases?

Yes, elevated or decreased levels of FOXP3 expression can serve as a biomarker for various diseases, including autoimmune conditions and certain cancers.

Can FOXP3 be used as a prognostic marker in cancer patients?

Yes, the expression of FOXP3 in tumor-infiltrating lymphocytes is studied as a potential prognostic marker in various cancers, with higher levels often associated with a better prognosis.

How does FOXP3 contribute to organ transplantation?

FOXP3 is crucial for immune tolerance in transplant recipients. Enhancing Treg function, possibly through manipulating FOXP3, is a focus for transplant research to prevent rejection.

How is FOXP3 protein used in cancer research and treatment?

FOXP3 is studied in cancer to understand its role in suppressing anti-tumor immune responses. Manipulating Tregs or targeting FOXP3 may be explored for cancer immunotherapy.

How does FOXP3 influence allergic responses?

FOXP3 helps regulate immune responses, including those involved in allergies. Dysfunction in FOXP3 or Tregs may contribute to allergic disorders.