Recombinant Human FRMD8 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | FRMD8-2522H |
Product Overview : | FRMD8 MS Standard C13 and N15-labeled recombinant protein (NP_114110) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface. Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 51.2 kDa |
AA Sequence : | MDGTEGSAGQPGPAERSHRSSVSSV GARAADVLVYLADDTVVPLAVENLP SLSAHELHRAVREVLQLPDIALDVF ALWLVSPLLEVQLKPKHQPYKLGRQ WPELLLRFTSAPDDDVAMDEPFLQF RRNVFFPKRRELQIHDEEVLRLLYE EAKGNVLAARYPCDVEDCEALGALV CRVQLGPYQPGRPAACDLREKLDSF LPAHLCKRGQSLFAALRGRGARAGP GEQGLLNAYRQVQEVSSDGGCEAAL GTHYRAYLLKCHELPFYGCAFFHGE VDKPAQGFLHRGGRKPVSVAISLEG VHVIDSREKHVLLGLRFQELSWDHT SPEEEEPILWLEFDGDSEGTPVNKL LKIYSKQAELMSSLIEYCIELSQAA EPAGPQDSATGSPSDPSSSLAPVQR PKLRRQGSVVSSRIQHLSTIDYVED GKGIRRVKPKRTTSFFSRQLSLGQG SYTVVQPGDSLEQGTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | FRMD8 FERM domain containing 8 [ Homo sapiens (human) ] |
Official Symbol : | FRMD8 |
Synonyms : | FRMD8; FERM domain containing 8; FERM domain-containing protein 8; FKSG44; FLJ90369; FLJ32216; MGC31785; |
Gene ID : | 83786 |
mRNA Refseq : | NM_031904 |
Protein Refseq : | NP_114110 |
MIM : | 618337 |
UniProt ID : | Q9BZ67 |
Products Types
◆ Recombinant Protein | ||
Frmd8-3085M | Recombinant Mouse Frmd8 Protein, Myc/DDK-tagged | +Inquiry |
FRMD8-3363M | Recombinant Mouse FRMD8 Protein, His (Fc)-Avi-tagged | +Inquiry |
FRMD8-1574R | Recombinant Rhesus Macaque FRMD8 Protein, His (Fc)-Avi-tagged | +Inquiry |
FRMD8-4205H | Recombinant Human FRMD8 Protein, GST-tagged | +Inquiry |
FRMD8-2049R | Recombinant Rat FRMD8 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FRMD8-6136HCL | Recombinant Human FRMD8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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